2020 Fiscal Year Final Research Report
Central circuitries underlying sympathetic adjustments to exercise
| Project/Area Number |
18H03151
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 59020:Sports sciences-related
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| Research Institution | Tottori University |
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Principal Investigator |
Koba Satoshi 鳥取大学, 医学部, 准教授 (40565743)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | セントラルコマンド / 光遺伝学 / 交感神経系 / 運動神経系 / 中脳 / 延髄 / 歩行 / 血圧 |
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| Outline of Final Research Achievements |
The results showed that midbrain neurons projecting the medulla, that are excited by exercise, are capable of eliciting locomotor and cardiovascular responses via sympatho-motor activation. Further, these neurons were required for fine regulation of motor coordination and autonomic cardiovascular adjustments during locomotor exercise. The study demonstrated a part of central circuitries for central command.
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| Free Research Field |
自律神経生理学
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| Academic Significance and Societal Importance of the Research Achievements |
19世紀末には議論されていた運動時交感神経活性の脳メカニズムは，現在も未解明である．運動発現のために生じる脳活性(セントラルコマンド，CC)は自律神経系も制御すると考えられる．本研究では遺伝子工学を用いた先端技術を融合させたin vivo生理実験から，CCの脳内回路の一端を解明した．本成果は，古典課題「運動時交感神経活性の脳メカニズムの解明」を解決へと導くだけでなく，Exercise is medicineの根幹メカニズムの解明にも資する．
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