2022 Fiscal Year Final Research Report
Study on wireless temperature measurement and heating technology for low invasive hyperthermia for malignant tumors.
| Project/Area Number |
18H03545
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 90130:Medical systems-related
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| Research Institution | Akita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
齊藤 元 岩手医科大学, 医学部, 教授 (20323149)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Keywords | ハイパーサーミア / 誘導加熱 / 低侵襲治療 / ワイヤレス温度計測 / 末期ガン / QOL / 感温磁性体微粒子 |
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| Outline of Final Research Achievements |
In this research, we aim to develop a minimally invasive thermal treatment technology to improve the quality of life (QOL) of patients with end-stage respiratory cancer. In this application, we have developed a 'wireless temperature measurement technology' that uses 'Low Curie Point Ferromagnetic Particles (FILCT)' injected into the tumor as a probe for temperature measurement, and a 'wireless temperature measurement and heating device' for hyperthermia that selectively heats only the tumor to a constant temperature of 45°C from the body surface with a high-frequency magnetic field. Furthermore, envisioning clinical application, we have improved the heating efficiency by doubling the frequency of the applied magnetic field, and implemented a 'magnetic flux application detection unit' that integrates the magnetic field application coil and the detection coil, among other things, we have developed various elemental technologies and made the challenges of this method evident.
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| Free Research Field |
医用システム工学
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| Academic Significance and Societal Importance of the Research Achievements |
従来のハイパーサーミアでは患部をピンポイントで加温するのが困難であり，治療時に温度センサを刺入しなければならない点が課題であった．本研究は，患部への1回の注射で半年以上の長期間安定して患部に留まり繰り返し発熱が期待できる粒径100μmのインプラントを用いており，且つ，非侵襲的に温度をモニタリングできるハイパーサーミア技術は国内外でも類を見ない．本申請では，磁場印加検知ユニットの最適化，印加磁場の高周波数化を図り，多点温度計測によりインプラント周辺の発熱特性を評価する等，要素技術を構築すると共に，体表面から30mmの深部までハイパーサーミア可能な「ワイヤレス温度計測・加熱装置」を実現した．
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