Study for mesenchymal stem cells derived from the two different origin

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K06264
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 44020:Developmental biology-related
• Research Institution: Kumamoto University
• Principal Investigator: Era Takumi 熊本大学, 発生医学研究所, 教授 (00273706)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 間葉系幹細胞

Outline of Final Research Achievements

Mesenchymal stem cells (MSCs) isolated from adult human tissues are capable of proliferating in vitro and maintaining their multipotency, making them attractive cell sources for regenerative medicine. However, the availability and capability of self-renewal under current preparation regimes are limited. Induced pluripotent stem cells (iPSCs) now offers an alternative, similar cell source to MSCs. Herein, we established new methods for differentiating hiPSCs into MSCs via mesoderm-like and neuroepithelium-like cells. Both derived MSC populations exhibited self-renewal and multipotency, as well as therapeutic potentials in mouse models of skin wounds, pressure ulcers, and osteoarthritis. Interestingly, the therapeutic effects differ between the two types of MSCs in the disease models, suggesting that the therapeutic effect depends on the cell origin. Our results provide valuable basic insights for the clinical application of such cells.

Free Research Field

幹細胞医学

Academic Significance and Societal Importance of the Research Achievements

この研究成果は、iPS細胞由来MSCの臨床での治療効果の基盤的知見となる。また個体からMSCと採取することにかわり、iPS細胞から同一的なMSCを将来誘導、分離、増幅するために役立つ知見となる。