2021 Fiscal Year Final Research Report
The role of taste receptors in immunology
| Project/Area Number |
18K06713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47040:Pharmacology-related
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
SAEKI Mayumi 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 主席研究員 (00462771)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Keywords | 免疫 / T細胞 / 味覚受容体 |
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| Outline of Final Research Achievements |
Our previous study has reported that the involvement of taste receptors in the efficacy of sublingual immunotherapy. In the present study, we investigated that the role of taste receptor in T cells. Cytokine expression by T cell activation signal was suppressed in taste receptor‐expressing cells, compared to wild type cells. Taste receptor and their ligands may inhibit the activation of T cells.
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| Free Research Field |
アレルギー学
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| Academic Significance and Societal Importance of the Research Achievements |
以前の臨床研究において、我々は、舌下免疫療法の奏功に苦味受容体が関与する可能性を報告したが、本研究で、はじめて、苦味受容体が実際T細胞の活性化に影響を与えることを示した。今後、更に研究を進めることにより、舌下免疫療法の奏功機序の解明につながることが期待される。
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