Analysis of immunoregulatory mechanisms mediated by paired receptors

2022 Fiscal Year Final Research Report

• Project/Area Number: 18K07176
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49070:Immunology-related
• Research Institution: Kanazawa Medical University
• Principal Investigator: SAITO Fumiji 金沢医科大学, 医学部, 助教 (20569016)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Keywords: ペア型レセプター / 抑制化型レセプター / マクロファージ

Outline of Final Research Achievements

Upon infection with pathogens, the immune system is initiated the suppressing system for preventing an excessive immune response along with the activating system for eliminating pathogens. In this study, we examined the functions of paired receptors that has been largely unknown in the brain. We found that the expression of paired inhibitory receptors on brain macrophages was not only increased after LPS administration, but also the expression of an inhibitory cytokine was increased. It is suggested that paired inhibitory receptors were involved in immunosuppression in the brain.

Free Research Field

免疫学

Academic Significance and Societal Importance of the Research Achievements

この研究により、抑制化型レセプターが脳マクロファージに発現し、免疫抑制化に関わっていることが示唆された。さらに詳細な研究を進めることにより、病原体感染時に脳の中における免疫反応の全容が解明され、暴走する免疫システムを押さえ込む治療法の開発に貢献することが期待される。病原体感染（近年では新型コロナウイルスを含む）による脳炎、脳症を発症するケースもあり、学術的意義や社会的意義が十分にあると考える。