Analysis of antioxidative mechanism of "Hojin-zai", a traditional Kampo medicine, and it application to the new prooxidant therapy.

2022 Fiscal Year Final Research Report

• Project/Area Number: 18K07437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Tsukuba University of Technology
• Principal Investigator: Hirayama Aki 筑波技術大学, 保健科学部, 教授 (20323298)
• Co-Investigator(Kenkyū-buntansha): 植田 敦志 筑波大学, 医学医療系, 准教授 (00708448)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Keywords: 牛車腎気丸 / 桂枝茯苓丸 / 毛細血管 / 細動脈 / 血流速度 / 一酸化窒素

Outline of Final Research Achievements

This study aimed to clarify the bioprotective mechanism of goshajinkigan (GJG), a kampo prescript, in comparison with keishibukuryogan (KBG), a typical kampo anti-oketsu prescription. The analysis made by live-imagings of the murine and rat animal models.
The main pharmacological target of GJG was the capillary vessels, while that of KBG was the arterioles. GJG enhanced the blood flow through the increase of capillary blood flow velocity and this effect was nitric oxide (NO) independent. In contrast, KBG induced vasodilation through NO dependent mechanism.

Free Research Field

内科学

Academic Significance and Societal Importance of the Research Achievements

日本漢方の実臨床では，証に基づく処方選択が為される．この経験則に基づく治療方針の有用性は幅広く認知されているが，現代薬理学的な証明は少ない．本研究成果は，牛車腎気丸および他の駆お血剤に関する経験的な随証治療にに対し，現代科学的な論拠を与えるものである．