The impact of frailty on the cardiovascular diseases

2022 Fiscal Year Annual Research Report

• Project/Area Number: 18K07471
• Research Institution: Kagoshima University
• Principal Investigator: 奥井 英樹 鹿児島大学, 医歯学総合研究科, 客員研究員 (70815620)
• Co-Investigator(Kenkyū-buntansha): 池田 義之 鹿児島大学, 医歯学域医学系, 准教授 (00573023) ; 窪薗 琢郎 鹿児島大学, 医歯学域医学系, 講師 (00598013) ; 大石 充 鹿児島大学, 医歯学域医学系, 教授 (50335345) ; 二宮 雄一 鹿児島大学, 医歯学総合研究科, 特任助教 (40722575)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Keywords: 心房細動 / 栄養 / フレイル / 動脈硬化 / 生活習慣病

Outline of Annual Research Achievements

本研究は、フレイルの主たる要因である低栄養・栄養障害と、心房細動との関連を臨床的に明らかにし、栄養介入を軸としたフレイル介入により、心房細動発症を予防しうるという仮説を証明することを目的としている。
フレイルにはサルコペニアを主とした身体的要素と、孤立を主とした社会的要素、そして認知症を主とした精神的要素から成り立っている。身体的フレイルの原因であるサルコペニアの要因として、低栄養・栄養障害が挙げられること、精神的フレイルの原因である認知症にはアルツハイマー以外にも動脈硬化を基盤とした血管性も多いことや、動脈硬化は高血圧・脂質異常症・糖尿病を主体とした生活習慣や肥満が関係していることまでを考慮し、1. 栄養（低栄養、メタボリック症候群（過栄養・腹囲長超過））、2. 身体活動、3. 動脈硬化性心血管疾患、4.心房細動　これらの関連を広く詳細に検討を行った。 その結果、I. フレイル・サルコペニアの主たる要因である低栄養が、様々な心血管疾患の予後不良因子であること、II. 動脈の石灰化は高度の血管狭窄を来し、動脈硬化性心血管疾患の発症や血管性認知症の発症を経てフレイルを来すが、低栄養はこの動脈の石灰化をも促進すること、III. 腹囲長が超過しているメタボリック症候群やサルコペニックオベシティーにある患者では、その後の心房細動発症のリスクとなることを、明らかにした。また栄養を評価する際、14.89 × Alb (g/dl) ＋ 41.7 × 現体重 (kg) / 理想体重 (kg)で産出されるGeriatric Nutritional Risk Index（GNRI）やコリンエステラーゼ（ChE)が有用であることを明らかにした。我々のこれまでの検討により、GNRIやChEを指標とした栄養評価と適切な栄養介入の重要性が明確となった。

Research Products

• [Journal Article] Adventitial Cystic Disease in the Popliteal Artery Diagnosed by Intravascular Ultrasound Imaging (2023)
  • Author(s): Miyauchi Eiji、Okui Hideki、Yuasa Toshinori、Oketani Naoya、Ohishi Mitsuru
  • Journal Title: Cureus Volume: 15 Pages: e34362
  • DOI: 10.7759/cureus.34362
  • Peer Reviewed / Open Access
• [Journal Article] Association between the number of Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria and clinical outcomes in patients with acute coronary syndrome (2023)
  • Author(s): Shimono Hirokazu、Tokushige Akihiro、Kanda Daisuke、Ohno Ayaka、Hayashi Masao、Fukuyado Mana、Akao Mitsumasa、Kawasoe Mariko、Arikawa Ryo、Otsuji Hideaki、Chaen Hideto、Okui Hideki、Oketani Naoya、Ohishi Mitsuru
  • Journal Title: Journal of Cardiology Volume: 81 Pages: 553～563
  • DOI: 10.1016/j.jjcc.2023.01.003
  • Peer Reviewed / Open Access
• [Journal Article] Changes in Satisfaction with Meaningful Activities and Onset of Depressive Symptoms among Community-Dwelling Japanese Older Adults: A Population-Based Study Before and During the COVID-19 Pandemic (2023)
  • Author(s): Maruta Michio、Tabira Takayuki、Shimokihara Suguru、Makizako Hyuma、Ikeda Yuriko、Han Gwanghee、Akasaki Yoshihiko、Hidaka Yuma、Nakahara Rena、Kamasaki Taishiro、Kukizaki Wataru、Kubozono Takuro、Ohishi Mitsuru
  • Journal Title: Journal of the American Medical Directors Association Volume: 24 Pages: 702～709.e3
  • DOI: 10.1016/j.jamda.2023.03.010
  • Peer Reviewed / Open Access
• [Journal Article] Development of predictive equation and score for 5-year metabolic syndrome incidence in Japanese adults (2023)
  • Author(s): Salim Anwar Ahmed、Kawasoe Shin、Kubozono Takuro、Ojima Satoko、Kawabata Takeko、Hashiguchi Hiroshi、Ikeda Yoshiyuki、Miyata Masaaki、Miyahara Hironori、Tokushige Koichi、Nishio Yoshihiko、Ohishi Mitsuru
  • Journal Title: PLOS ONE Volume: 18 Pages: e0284139
  • DOI: 10.1371/journal.pone.0284139
  • Peer Reviewed / Open Access
• [Journal Article] Development of a risk prediction score and equation for chronic kidney disease: a retrospective cohort study (2023)
  • Author(s): Kawasoe Shin、Kubozono Takuro、Salim Anwar Ahmed、Yoshimine Haruhito、Mawatari Seiichi、Ojima Satoko、Kawabata Takeko、Ikeda Yoshiyuki、Miyahara Hironori、Tokushige Koichi、Ido Akio、Ohishi Mitsuru
  • Journal Title: Scientific Reports Volume: 13 Pages: 5001
  • DOI: 10.1038/s41598-023-32279-z
  • Peer Reviewed / Open Access
• [Journal Article] Clinical significance of atherosclerotic risk factors differs in early and advanced stages of plaque formation: A longitudinal study in the general population (2023)
  • Author(s): Ojima Satoko、Kubozono Takuro、Kawasoe Shin、Kawabata Takeko、Salim Anwar Ahmed、Ikeda Yoshiyuki、Miyata Masaaki、Miyahara Hironori、Tokushige Koichi、Ohishi Mitsuru
  • Journal Title: International Journal of Cardiology Volume: 379 Pages: 111～117
  • DOI: 10.1016/j.ijcard.2023.02.037
  • Peer Reviewed / Open Access
• [Journal Article] Social Frailty and Meaningful Activities among Community-Dwelling Older Adults with Heart Disease (2022)
  • Author(s): Akasaki Yoshihiko、Tabira Takayuki、Maruta Michio、Makizako Hyuma、Miyata Masaaki、Han Gwanghee、Ikeda Yuriko、Nakamura Atsushi、Shimokihara Suguru、Hidaka Yuma、Kamasaki Taishiro、Kubozono Takuro、Ohishi Mitsuru
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 19 Pages: 15167～15167
  • DOI: 10.3390/ijerph192215167
  • Peer Reviewed / Open Access
• [Journal Article] Insufficient blood pressure control is independently associated with increased arterial stiffness (2022)
  • Author(s): Kawabata Takeko、Kubozono Takuro、Ojima Satoko、Kawasoe Shin、Akasaki Yuichi、Salim Anwar Ahmed、Ikeda Yoshiyuki、Miyata Masaaki、Takenaka Toshihiro、Ohishi Mitsuru
  • Journal Title: Hypertension Research Volume: 45 Pages: 1861～1868
  • DOI: 10.1038/s41440-022-01039-3
  • Peer Reviewed / Open Access
• [Journal Article] Association of Sleep Duration and Cardio-Ankle Vascular Index in Community-Dwelling Older Adults (2022)
  • Author(s): Masumitsu Tomomi、Kubozono Takuro、Miyata Masaaki、Makizako Hyuma、Tabira Takayuki、Takenaka Toshihiro、Kawasoe Shin、Tokushige Akihiro、Niwa Sayoko、Ohishi Mitsuru
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Pages: 1864～1871
  • DOI: 10.5551/jat.63594
  • Peer Reviewed / Open Access
• [Journal Article] Association of blood pressure and dietary intake of Sunomono, Japanese vinegared side dishes, in community-dwelling Japanese: A cross-sectional study (2022)
  • Author(s): Kanouchi Hiroaki、Yamashita Mikako、Kaimoto Kaori、Kuwabara Akiko、Kawakami Yukiko、Takenaka Shigeo、Koriyama Chihaya、Kuwahata So、Takenaka Toshihiro、Akasaki Yuichi、Kubozono Takuro、Miyata Masaaki、Ohishi Mitsuru
  • Journal Title: Heliyon Volume: 8 Pages: e09505～e09505
  • DOI: 10.1016/j.heliyon.2022.e09505
  • Peer Reviewed / Open Access
• [Journal Article] Association between satisfaction with meaningful activities and social frailty in community-dwelling Japanese older adults (2022)
  • Author(s): Miyata Hironori、Maruta Michio、Makizako Hyuma、Han Gwanghee、Ikeda Yuriko、Nakamura Atsushi、Tokuda Keiichiro、Shimokihara Suguru、Akaida Shoma、Hidaka Yuma、Akasaki Yoshihiko、Kubozono Takuro、Ohishi Mitsuru、Tabira Takayuki
  • Journal Title: Archives of Gerontology and Geriatrics Volume: 100 Pages: 104665～104665
  • DOI: 10.1016/j.archger.2022.104665
  • Peer Reviewed / Open Access
• [Presentation] THE ONE-TWO PUNCH: Complication of coronary arterycalcification and malnutrition worsen prognosis of patients with stablecoronary artery disease. (2023)
  • Author(s): Kanda D, Ikeda Y, Ohmure K, Anzaki K, Sonoda T, Tokushige A, Ohishi M.
  • Organizer: 72th Annual Scientific Session of the American College of Cardiology
  • Int'l Joint Research
• [Presentation] Effect of defecation status on blood pressure variability. (2023)
  • Author(s): Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Ikeda Y, Tezuka A, Kuwahata S, Takenaka T, Ohishi M.
  • Organizer: 第87回 日本循環器学会学術集会
• [Presentation] Association between weight gain after smoking cessation and future hypertension. (2023)
  • Author(s): Ninomiya Y, Kawasoe S, Kubozono T, Tokushige A, Ichiki H, Kamada H, Yoshimoto I, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
  • Organizer: 第87回 日本循環器学会学術集会
• [Presentation] Ability of machine learning algorithms to predict chronic kidney disease using health examination data. (2023)
  • Author(s): Kawasoe S, Kubozono T, Anwar Salim, Ojima S, Kawabata T, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
  • Organizer: 第87回 日本循環器学会学術集会
• [Presentation] Impact of living alone on prognosis of acute myocardial infarction patients undergoing percutaneous coronary intervention. (2023)
  • Author(s): Fukumoto D, Kanda D, Ikeda Y, Tokushige A, Ohmure K, Sonoda T, Anzaki K, Ohishi M.
  • Organizer: 第87回 日本循環器学会学術集会
• [Presentation] Characteristics of isolated diastolic hypertension which progresses to systolic diastolic hypertension. (2023)
  • Author(s): Sakoda T, Akasaki Y, Sasaki Y, Kawasoe S, Kubozono T, Ikeda Y, Ohishi M.
  • Organizer: 第87回 日本循環器学会学術集会
• [Presentation] Sex differences in future hypertension caused by increased abdominal circumference in middle-aged participants. (2022)
  • Author(s): Ninomiya Y, Kawasoe S, Kubozono T, Tokushige A, Ichiki H, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
  • Organizer: 71th Annual Scientific Session of the American College of Cardiology
  • Int'l Joint Research
• [Presentation] Impact of nutritional status on short-and long-term prognosis in acute myocardial infarction patients undergoing percutaneous coronary intervention. (2022)
  • Author(s): Kanda D, Ikeda Y, Takumi T, Anzaki K, Sonoda T, Tokushige A, Ohumare K, Ohishi M.
  • Organizer: 71th Annual Scientific Session of the American College of Cardiology
  • Int'l Joint Research
• [Presentation] Development of a score and an equation to predict 5-year chronic kidney disease using Japanese health checkup data. (2022)
  • Author(s): Kawasoe S, Kubozono T, Salim Anwar Ahmed, Ojima S, Kawabata T, Yoshimine H, Mawatari S, Ikeda Y, Miyahara H, Tokushige K, Ido A, Ohishi M.
  • Organizer: ESC Congress 2022
  • Int'l Joint Research
• [Presentation] Association between defecation status and blood pressure variability. (2022)
  • Author(s): Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Anwar Ahmed Salim, Ikeda Y, Ohishi M.
  • Organizer: The 29th Scientific Meeting of the International Society of Hypertension
  • Int'l Joint Research
• [Presentation] Association between increased abdominal circumference and future development of hypertension in mildly obese middle-aged individuals. (2022)
  • Author(s): Ninomiya Y, Kawasoe S, Kubozono T, Tokushige A, Ichiki H, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
  • Organizer: The 29th Scientific Meeting of the International Society of Hypertension
  • Int'l Joint Research
• [Presentation] Predictive ability for new-onset chronic kidney diseases by machine learning algorithm using health checkup data. (2022)
  • Author(s): Kawasoe S, Kubozono T, Ojima S, Kawabata T, Awar Armed Salim, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
  • Organizer: The 29th Scientific Meeting of the International Society of Hypertension
  • Int'l Joint Research
• [Presentation] Factors for new-onset isolated diastolic hypertension and progression to systolic hypertension in Japan. (2022)
  • Author(s): Sakoda T, Akasaki Y, Kawasoe S, Kubozono T, Sasaki Y, Ikeda Y, Ohishi M, Miyahara H, Tokushige K.
  • Organizer: The 29th Scientific Meeting of the International Society of Hypertension
  • Int'l Joint Research
• [Presentation] Differences in risk factors for developing hypertension when hypertension reference values are changed. (2022)
  • Author(s): Sakoda T, Akasaki Y, Kawasoe S, Kubozono T, Sasaki Y, Ikeda Y, Ohishi M, Miyahara H, Tokushige K.
  • Organizer: The 29th Scientific Meeting of the International Society of Hypertension
  • Int'l Joint Research
• [Presentation] Association between weight gain after smoking cessation and future hypertension. (2022)
  • Author(s): Ninomiya Y, Kawasoe S, Kubozono T, Tokushige A, Ichiki H, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
  • Organizer: AHA Scientific Sessions 2022
  • Int'l Joint Research
• [Presentation] Ability of machine learning algorithms to predict chronic kidney disease using health examination data from the Japanese general population. (2022)
  • Author(s): Kawasoe S, Kubozono T, Anwar Ahmed Salim, Ojima S, Kawabata T, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
  • Organizer: AHA Scientific Sessions 2022
  • Int'l Joint Research
• [Presentation] Clinical impact of C-reactive protein to albumin ratio on prognosis in patients with stable coronary artery disease after percutaneous coronary intervention. (2022)
  • Author(s): Anzaki K, Kanda D, Sonoda T, Ohmure K, Ikeda Y, Ohishi M.
  • Organizer: AHA Scientific Sessions 2022
  • Int'l Joint Research
• [Presentation] 低栄養は高齢者急性心筋梗塞（AMI）患者の死亡リスク因子になるか？ (2022)
  • Author(s): 神田大輔，池田義之，大牟禮健太，薗田剛嗣，安﨑和博，大石 充.
  • Organizer: 第64回 日本老年医学会学術集会
• [Presentation] 経皮的冠動脈形成術を受けた急性心筋梗塞患者の短期および長期の予後に対す栄養状態の影響. (2022)
  • Author(s): Kanda D, Ikeda Y, Takumi T, Anzaki K, Sonoda T, Ohmure K, Tokushige A, Ohishi M.
  • Organizer: 第30回 日本心血管インターベンション治療学会
• [Presentation] 低栄養-炎症-動脈硬化症候群はEVTを受けた高齢CLTI患者の予後不良因子である. (2022)
  • Author(s): Sonoda T, Kanda D, Ikeda Y, Anzaki K, Arikawa R, Ohmure K, Tokushige A, Takumi T, Ohishi M.
  • Organizer: 第30回 日本心血管インターベンション治療学会
• [Presentation] 地域在住高齢者における認知的フレイルと動脈硬化度の関連. (2022)
  • Author(s): 赤井田将真, 谷口善昭, 中井雄貴, 木内悠人, 立石麻奈, 白土大成, 竹中俊宏, 窪薗琢郎, 大石 充, 牧迫飛雄馬.
  • Organizer: 第9回 日本サルコペニア・フレイル学会大会