2021 Fiscal Year Final Research Report
Development of the optogenetic autoregulated cell transplantation for Parkinson's disease
| Project/Area Number |
18K07509
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52020:Neurology-related
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| Research Institution | Juntendo University |
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Principal Investigator |
Oyama Genko 順天堂大学, 大学院医学研究科, 准教授 (00407256)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Keywords | transplantation / iPS cell / Parkinson's disease / optogenetics |
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| Outline of Final Research Achievements |
In this study, we expressed Channelrhodopsin in Human Induced Pluripotent Stem Cells (iPSCs) and differentiated it into dopamine neurons.We confirmed that the neuronal activities of photoreactive dopamine neurons were increased by the blue light and succeeded in finding the adequate condition for phot-stimulation. We studied the potential of Local field potential (LFP) as a biomarker to modulate dopamine neurons. Our result may lead to the development of "the self-regulate dopamine neuron transplantation."
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| Free Research Field |
神経内科学
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| Academic Significance and Societal Importance of the Research Achievements |
パーキンソン病患者に対するiPSC由来ドパミン神経細胞移植では、移植片のドパミン放出を制御可能にしない限り、ジスキネジアの問題は解決しないことが予想される。本研究の結果から自律調整性ドパミン神経細胞移植療法がヒトで応用可能になれば、細胞移植療法後に予想されるジスキネジアの問題が解決することが期待できる。
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