2020 Fiscal Year Final Research Report
Cross-sectional and prospective studies of the elucidation of actual status of dementia in a Japanese older residents.
| Project/Area Number |
18K07565
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉田 大悟 九州大学, 医学研究院, 助教 (10596828)
神庭 重信 九州大学, 医学研究院, 教授 (50195187)
二宮 利治 九州大学, 医学研究院, 教授 (30571765)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | 認知症 / 有病率 / 横断調査 / 縦断調査 / 危険因子 |
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| Outline of Final Research Achievements |
In 2017, a total of 2,202 Japanese older residents participated in the dementia survey in a Hisayama town (participation rate: 94.1%). Among these, 346 participants were diagnosed as having dementia (crude prevalence:e 15.7%), and 69.7% of subjects with dementia obtained a certification of long-term care insurance. The cross-sectional study using brain magnetic resonance imaging demonstrated that higher serum glycated albumin and higher glycated albumin/hemoglobin A1c ratio are significantly associated with hippocampal atrophy.
In a prospective study of dementia, increased serum soluble triggering receptor expressed on myeloid cells 2 (sTREM2) levels, higher serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, and short and long duration of sleep are significant risk factors for the development of dementia.
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| Free Research Field |
疫学
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| Academic Significance and Societal Importance of the Research Achievements |
2012年の全国調査以降にわが国の地域高齢住民における認知症の有病率を調査した研究はなく、本研究で得られた認知症の有病率や介護保険の認定状況は今後の認知症施策に貢献するものと考えられる。また、横断調査や縦断調査の成績から認知症の発症には、適切な睡眠時間の確保という生活習慣だけでなく、脳内炎症や心機能の維持が重要であることを明らかにした。これらの知見は認知症の予防法の確立に寄与するだけでなく、ひいては国民の健康寿命の延伸につながるものと考えられる。
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