統合失調症と気分障害のω3脂肪酸と脳部位間結合障害の関連を明らかにする縦断研究

2019 Fiscal Year Research-status Report

• Project/Area Number: 18K07570
• Research Institution: Wakayama Medical University
• Principal Investigator: 高橋 隼 和歌山県立医科大学, 医学部, 講師 (10508021)
• Co-Investigator(Kenkyū-buntansha): 鵜飼 聡 和歌山県立医科大学, 医学部, 教授 (80324763) [Withdrawn] ; 辻 富基美 和歌山県立医科大学, 医学部, 准教授 (10347586) ; 石田 卓也 和歌山県立医科大学, 医学部, 博士研究員 (10549728) ; 山田 信一 和歌山県立医科大学, 医学部, 助教 (70549716) ; 山本 眞弘 和歌山県立医科大学, 医学部, 助教 (80423937) ; 坂本 裕司 和歌山県立医科大学, 医学部, 助教 (20535497) [Withdrawn] ; 上西 優介 和歌山県立医科大学, 医学部, 助教 (20648464) ; 奥平 和也 和歌山県立医科大学, 医学部, 助教 (70644087)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: 統合失調症 / 気分障害 / オメガ3脂肪酸 / 脳部位間結合性

Outline of Annual Research Achievements

本研究では、オメガ３脂肪酸と脳部位間結合性に着目して統合失調症と気分障害における認知機能障害の病態生理を解明し、さらに認知機能障害が社会機能と生活の質（QOL）とどのように関連するかを明らかにする。本研究では、末梢血オメガ３脂肪酸の低下と神経炎症・酸化ストレスの増強が脳白質神経線維と灰白質皮質の器質的変化を引き起こし、脳部位間結合性を障害するという仮説をたてており、具体的には、健常対照群と比較して疾患群で有意差をもつ脳画像変化を明らかにし、脳画像変化と末梢血オメガ３脂肪酸、炎症・酸化ストレスマーカー、臨床指標（認知機能、社会機能アウトカム）の関連を検討する。
2019年度は被験者のリクルートを推進し、2019年3月時点で予定被験者数（200名）の約半数（約90名）のリクルートを終了した。画像解析技術については、研究分担者（山田信一）がDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munichに出向し、主に脳構造画像（皮質厚、脳白質神経線維）の最新の画像解析手法を習得し、研究代表者とともに統合失調症および気分障害患者を対象とした画像研究の成果を論文・学会発表した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

2018年度に研究体制を整え、2019年度はリクルートを推進できた。

Strategy for Future Research Activity

2020年度中にはリクルートを終了したい。

Causes of Carryover

被験者リクルートが目標に達しなかったため。次年度使用額は来年度に被験者をリクルートした際の検査費用に用いる。

Research Products

• [Journal Article] Effect of aerobic exercise combined with cognitive remediation on cortical thickness and prediction of social adaptation in patients with schizophrenia (2020)
  • Author(s): Takahashi Shun、Keeser Daniel、Rauchmann Boris-Stephan、Schneider-Axmann Thomas、Keller-Varady Katriona、Maurus Isabel、Dechent Peter、Wobrock Thomas、Hasan Alkomiet、Schmitt Andrea、Ertl-Wagner Birgit、Malchow Berend、Falkai Peter
  • Journal Title: Schizophrenia Research Volume: 216 Pages: 397～407
  • DOI: 10.1016/j.schres.2019.11.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Widespread white matter microstructural abnormalities and cognitive impairment in schizophrenia, bipolar disorder, and major depressive disorder: Tract-based spatial statistics study (2020)
  • Author(s): Yamada Shinichi、Takahashi Shun、Ohoshi Yuji、Ishida Takuya、Tsuji Tomikimi、Shinosaki Kazuhiro、Terada Masaki、Ukai Satoshi
  • Journal Title: Psychiatry Research: Neuroimaging Volume: 298 Pages: 111045～111045
  • DOI: 10.1016/j.pscychresns.2020.111045
  • Peer Reviewed
• [Journal Article] Effect of aerobic exercise on cortical thickness in patients with schizophrenia -a dataset (2020)
  • Author(s): Takahashi S, Keeser D, Rauchmann BS, Schneider-Axmann T, Keller-Varady K, Maurus I, Dechent P, Wobrock T, Hasan A, Schmitt A, Ertl-Wagner B, Malchow B, Falkai P.
  • Journal Title: Data in Brief Volume: 30 Pages: 105517
  • DOI: 10.1016/j.dib.2020.105517
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The impact of endurance training and table soccer on brain metabolites in schizophrenia (2020)
  • Author(s): Rauchmann B, Ghaseminejad F, Keeser D, Keller-Varady K, Schneider-Axmann T, Takahashi S, Karali T, Helms G, Dechent P, Maurus I, Hasan A, Wobrock T, Ertl-Wagner B, Schmitt A, Malchow B, Falkai P.
  • Journal Title: Brain Imaging and Behavior Volume: 14 Pages: 515-526
  • DOI: 10.1007/s11682-019-00198-1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: a tract-specific analysis study (2019)
  • Author(s): Ohoshi Y, Takahashi S, Yamada S, Ishida T, Tsuda K, Tsuji T, Terada M, Shinosaki K, Ukai S.
  • Journal Title: Brain and Behavior Volume: 9 Pages: e01357
  • DOI: 10.1002/brb3.1357
  • Peer Reviewed / Open Access
• [Journal Article] Neurobiological effects of aerobic exercise, with a focus on patients with schizophrenia (2019)
  • Author(s): Maurus I, Hasan A, Roh A, Takahashi S, Rauchmann B, Keeser D, Malchow B, Schmitt A, Falkai P.
  • Journal Title: European Archives of Psychiatry and Clinical Neuroscience Volume: 269 Pages: 499-515
  • DOI: 10.1007/s00406-019-01025-w
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 統合失調症のオメガ3脂肪酸仮説 (2019)
  • Author(s): 髙橋隼, 里神和美, 鵜飼聡.
  • Journal Title: 精神科治療学 Volume: 34 Pages: 1007-1012
• [Presentation] Reduced efields show up in schizophrenia and major depression - A prefrontal tDCS simulation study (2019)
  • Author(s): Takahashi S, Mizutani Y, Karali T, Dechantsreiter E, Papazova I, Mezger E, Bulubas L, Stoecklein S, Thielscher A, Padberg F, Keeser D.
  • Organizer: OHBM Annual Meeting
  • Int'l Joint Research
• [Presentation] Neuroimaging effect of aerobic exercise on cortical thickness in patients with schizophrenia (2019)
  • Author(s): Takahashi S, Keeser D, Rauchmann B, Schneider-Axmann T, Keller-Varady K, Maurus I, Dechent P, Wobrock T, Hasan A, Schmitt A, Ertl-Wagner B, Malchow B, Falkai P
  • Organizer: OHBM Annual Meeting
  • Int'l Joint Research
• [Presentation] WM abnormalities and their relationship with cognitive impairment in SZ, BD, and MDD (2019)
  • Author(s): Yamada S, Takahashi S, Ishida T, Ohoshi Y, Tsuji T, Shinosaki K, Terada M, Ukai S.
  • Organizer: OHBM Annual Meeting
  • Int'l Joint Research
• [Presentation] Assessment of cortical excitability using TMS techniques in neuropsychiatric disorders (2019)
  • Author(s): Takahashi S.
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology
  • Int'l Joint Research / Invited
• [Presentation] Reduction of simulated e-fields in schizophrenia and major depression during prefrontal tDCS (2019)
  • Author(s): Takahashi S.
  • Organizer: 13th International Conference on Complex Medical Engineering
  • Int'l Joint Research / Invited
• [Presentation] SIMNIBS simulations in schizophrenic, depressive patients and healthy subjects - how to better individualize neuromodulation? (2019)
  • Author(s): Takahashi S, Mizutani Y.
  • Organizer: BrainSTIM 2019
  • Int'l Joint Research / Invited