A metagenomic approach to unveil the association between gut microbiota and molecular pathophysiology of schizophrenia

2023 Fiscal Year Final Research Report

• Project/Area Number: 18K07601
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Okayama University
• Principal Investigator: OKAHISA YUKO 岡山大学, 大学病院, 講師 (90583097)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Keywords: 統合失調症 / 腸内細菌叢 / メタゲノム

Outline of Final Research Achievements

The purpose of this study is to reveal the molecular pathophysiology of schizophrenia. The microbiota in stool samples obtained from 30 patients with schizophrenia and 30 healthy control were determined by 16S rRNA gene sequencing but failed to identify pathogenesis of schizophrenia. We intend to metabologenomic analysis in further study.

Free Research Field

分子精神医学

Academic Significance and Societal Importance of the Research Achievements

日本人統合失調症患者で網羅的な腸内細菌叢解析を行い基礎的なデータの構築ができたことは、病態解明に向けた有意義な取り組みであったと考える。今回の解析では病態の解明につながる結果は得られなかったが、この研究を手掛かりにより多くのサンプルでの解析やメタボローム解析を行い、病態解明につなげたい。