Detecting the neural oscillation deficits during abnormal emotional regulation in schizophrenia patients

2021 Fiscal Year Annual Research Report

• Project/Area Number: 18K07604
• Research Institution: Kyushu University
• Principal Investigator: 平野 羊嗣 九州大学, 大学病院, 講師 (90567497)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: 統合失調症 / 情動制御 / 社会機能障害 / ガンマオシレーション / 脳波 / 脳磁図 / fMRI

Outline of Annual Research Achievements

統合失調症は、陽性症状や陰性症状、認知機能障害に加え、情動面の制御の障害を有し、それらが重篤な社会機能障害をもたらす難治性精神疾患である。しかしながら、統合失調症患者における情動制御異常の病態生理は殆ど解明されていない。本研究は、統合失調症患者の情動制御異常の病態生理を解明し、最終的には治療に応用することを目標としている。最終年度は健常者31名と統合失調症32名を対象に、情動を制御する際の、前頭部のガンマオシレーションの変化を脳波で計測し、その解析を行った。その結果、健常者に比べ統合失調症では情動制御時に前頭部のガンマオシレーション異常が生じていることがわかった。また、同時に健常者31人を対象に40 Hzと42 Hzの刺激を用いた周波数弁別課題を行い、トレーニング後に弁別能が改善することと脳波の同期度が変化することも見出した。結果の一部は、国内外の学会で発表し、統合失調症のニューロフィードバックに関する包括的Reviewが国際英文誌に受理された。また、統合失調症の認知機能や脳構造異常、脳機能異常、神経同期活動異常に関する研究論文や総論が計12本国際専門誌に受理された。さらに、ニューロフィードバック研究に必要な革新的な解析技術（リアルタイム時間周波数解析）の特許申請も行った。今後は、本研究で得られた結果を元に、統合失調症の感情制御異常の背景となっているガンマオシレーション異常をリアルタイムのニューロフィードバック手法で改善する研究を進めていく。

Research Products

• [Int'l Joint Research] Harvard Medical School(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: Harvard Medical School
• [Int'l Joint Research] UNSW Sydney(オーストラリア)
  • Country Name: AUSTRALIA
  • Counterpart Institution: UNSW Sydney
• [Journal Article] Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment (2022)
  • Author(s): Wada M, Noda Y, Iwata Y, Tsugawa S, Yoshida K, Tani H, Hirano Y, et al
  • Journal Title: Molecular Psychiatry Volume: in press Pages: -
  • DOI: 10.1038/s41380-022-01572-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transdiagnostic Comparisons of Intellectual Abilities and Work Outcome in Patients with Mental Disorders: A Multicentre Study (2022)
  • Author(s): Sumiyoshi C, Ohi K, Fujino H, Yamamori H, Fujimoto M, Yasuda Y, Uno Y, Takahashi J, Morita K, Katsuki A, Yamamoto M, Okahisa Y, Sata A, Katsumoto E, Koeda M, Hirano Y, et al
  • Journal Title: BJPsych Open Volume: in press Pages: -
  • Peer Reviewed / Open Access
• [Journal Article] Recent Advances and Future Directions in Brain MR Imaging Studies in Schizophrenia: Toward Elucidating Brain Pathology and Developing Clinical Tools (2022)
  • Author(s): Shinsuke Koike, Akiko Uematsu, Daiki Sasabayashi, Norihide Maikusa, Tsutomu Takahashi, Kazutaka Ohi, Shinichiro Nakajima, Yoshihiro Noda, Yoji Hirano
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: in press Pages: -
  • DOI: 10.2463/mrms.rev.2021-0050
  • Peer Reviewed / Open Access
• [Journal Article] Toward Recovery in Schizophrenia: Current Concepts, Findings, and Future Research Directions (2022)
  • Author(s): Toshiaki Onitsuka, Yoji Hirano, Takanobu Nakazawa, Kayo Ichihashi, Kenichiro Miura, Ken Inada, Ryo Mitoma, Norio Yasui_Furukori, Ryota Hashimoto
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: in press Pages: -
  • DOI: 10.1111/pcn.13342
  • Peer Reviewed / Open Access
• [Journal Article] Multi-modal imaging of the auditory-larynx motor network for voicing perception (2022)
  • Author(s): Shunsuke Tamura, Nobuyuki Hirose, Takako Mitsudo, Nobuhiko Hoaki, Itta Nakamura, Toshiaki Onitsuka, Yoji Hirano
  • Journal Title: NeuroImage Volume: 251 Pages: 118981-118981
  • DOI: 10.1016/j.neuroimage.2022
  • Peer Reviewed / Open Access
• [Journal Article] Trends in Big Data Analyses by Multicenter Collaborative Translational Research in Psychiatry (2022)
  • Author(s): Toshiaki Onitsuka, Yoji Hirano, Kiyotaka Nemoto, Naoki Hashimoto, Itaru Kushima, Daisuke Koshiyama, Michihiko Koeda, Tsutomu Takahashi, Yoshihiro Noda, Junya Matsumoto, Kenichiro Miura, Takanobu Nakazawa, Takatoshi Hikida, Kiyoto Kasai, Norio Ozaki, Ryota Hashimoto
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 76 Pages: 1-14
  • DOI: 10.1111/pcn.13311
  • Peer Reviewed / Open Access
• [Journal Article] Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial (2022)
  • Author(s): Yamasue H, Kojima M, Kuwabara H, ..Hirano Y, Onitsuka T, Kosaka H, Okada T
  • Journal Title: Brain Volume: 145 Pages: 490-499
  • DOI: 10.1093/brain/awab291
  • Peer Reviewed / Open Access
• [Journal Article] Current MEG Research in Psychiatry (2021)
  • Author(s): Yoji Hirano*, Peter J. Uhlhaas
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 647085
  • DOI: 10.3389/fpsyt.2021.647085
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lower Hippocampal Volume in Patients with Schizophrenia and Bipolar Disorder: A Quantitative MRI Study (2021)
  • Author(s): Jinya Sato, Yoji Hirano*, Noriaki Hirakawa, Junichi Takahashi, Naoya Oribe, Hironori Kuga, Itta Nakamura, Shogo Hirano, Takefumi Ueno, Osamu Togao, Akio Hiwatashi, Tomohiro Nakao, Toshiaki Onitsuka
  • Journal Title: Journal of Personalized Medicine Volume: 11 Pages: 121-121
  • DOI: 10.3390/jpm11020121
  • Peer Reviewed / Open Access
• [Journal Article] Effects of age and sex on eye movement characteristics (2021)
  • Author(s): Junichi Takahashi, Kenichiro Miura, Kentaro Morita, Michiko Fujimoto, Seiko Miyata, Kosuke Okazaki, Junya Matsumoto, Naomi Hasegawa, Yoji Hirano, Hidenaga Yamamori, Yuka Yasuda, Manabu Makinodan, Kiyoto Kasai, Norio Ozaki, Toshiaki Onitsuka, Ryota Hashimoto
  • Journal Title: Neuropsychopharmacology Reports Volume: 41 Pages: 152-158
  • DOI: 10.1002/npr2.12163
  • Peer Reviewed / Open Access
• [Journal Article] Recent updates of eye movement abnormalities in patients with schizophrenia: A scoping review (2021)
  • Author(s): Alexandra Wolf, Kazuo Ueda, Yoji Hirano*
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 75 Pages: 82-100
  • DOI: 10.1111/pcn.13188
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recent Findings on Neurofeedback Training for Auditory Hallucinations in Schizophrenia (2021)
  • Author(s): Yoji Hirano*, Shunsuke Tamura
  • Journal Title: Current Opinion in Psychiatry Volume: 34 Pages: 245-252
  • DOI: 10.1097/yco.000000000000
  • Peer Reviewed / Open Access
• [Journal Article] Eye Movement Abnormalities in Major Depressive Disorder (2021)
  • Author(s): Junichi Takahashi, Yoji Hirano*, Kenichiro Miura, Kentaro Morita, Michiko Fujimoto, Hidenaga Yamamori, Yuka Yasuda, Noriko Kudo, Emiko Shishido, Kosuke Okazaki, Tomoko Shiino, Tomohiro Nakao, Kiyoto Kasai, Ryota Hashimoto, Toshiaki Onitsuka
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 673443
  • DOI: 10.3389/fpsyt.2021.673443
  • Peer Reviewed / Open Access
• [Journal Article] Oscillatory brain network changes after transcranial magnetic stimulation treatment in patients with major depressive disorder (2021)
  • Author(s): Ryo Mitoma, Shunsuke Tamura, Hiroshi Tateishi, Takako Mitsudo, Ichiro Tanabe, Akira Monji, Yoji Hirano*
  • Journal Title: Journal of Affective Disorders Reports Volume: 7 Pages: 100277-100277
  • DOI: 10.1016/j.jadr.2021.100277
  • Peer Reviewed / Open Access
• [Journal Article] Current Findings and Perspectives on Aberrant Neural Oscillations in Schizophrenia (2021)
  • Author(s): Yoji Hirano*, Peter J. Uhlhaas
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 75 Pages: 358-368
  • DOI: 10.1111/pcn.13300
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 統合失調症におけるNMDA受容体とガンマオシレーション異常 (2021)
  • Author(s): 平野羊嗣
  • Journal Title: 医学のあゆみ Volume: 277 Pages: 953-959
  • Peer Reviewed
• [Journal Article] 統合失調症の神経活動異常と神経免疫異常 (2021)
  • Author(s): 平野羊嗣, 加藤隆弘
  • Journal Title: 生体の科学（特集：脳とからだ） Volume: 72 Pages: 434-437
  • Peer Reviewed
• [Presentation] Spontaneous and Evoked Neural Oscillation Abnormalities in Schizophrenia. (2021)
  • Author(s): Hirano Y
  • Organizer: 9th European Conference on Schizophrenia Research (Symposium Co-chair)
  • Int'l Joint Research / Invited
• [Presentation] Dynamic Neural Activity Changes After Transcranial Magnetic Stimulation Treatment in Patients with Major Depressive Disorder (2021)
  • Author(s): Hirano Y, Mitoma R, Tamura S, Tateishi H, Monji A
  • Organizer: The 2021 Society of Biological Psychiatry Annual Meeting
  • Int'l Joint Research
• [Presentation] Increased Theta/Alpha Source Activity and Default Mode Network Connectivity in Schizophrenia During Eyes-Closed Rest (2021)
  • Author(s): Nakhnikian A, Oribe N, Hirano S, Hirano Y, Levin M, Spencer K
  • Organizer: The 2021 Society of Biological Psychiatry Annual Meeting
  • Int'l Joint Research
• [Presentation] Eye-Movement Abnormalities among Patients with Schizophrenia (2021)
  • Author(s): Wolf A, Hirano Y
  • Organizer: 43rd European Conference on Visual Perception
  • Int'l Joint Research
• [Presentation] Attention to Sound Stimuli Modulates Gamma Oscillation: Towards Neurofeedback Training (2021)
  • Author(s): Hirano Y, Mitsudo T, Tamura S
  • Organizer: The 2021 Congress of The Schizophrenia International Research Society
  • Int'l Joint Research / Invited
• [Presentation] Cross-diagnostic Comparisons of Intellectual Ability and Work Outcome in Patients with Mental Disorders: A Multi-center Study (2021)
  • Author(s): Sumiyoshi C, Ohi K, Fujino H, Yamamori H, Fujimoto M, Yasuda Y, Uno Y, Takahashi J, Morita K, Katsuki A, Yamamoto M, Okahisa Y, Sata A, Katsumoto E, Koeda M, Hirano Y, Nakataki M, Hashimoto N, Makinodan M, Takahashi T, Nemoto N, Kishimoto T, Suzuki M, Sumiyoshi T, Hashimoto R
  • Organizer: The 2021 Congress of the Schizophrenia International Research Society
  • Int'l Joint Research
• [Patent(Industrial Property Rights)] 脳活動推定方法、脳活動推定装置および脳活動推定プログラム (2021)
  • Inventor(s): 平野羊嗣、中西翔一郎
  • Industrial Property Rights Holder: 平野羊嗣、中西翔一郎
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2021-118565