Developemnt for correction method in OEF image to overcome factors deteriorating image accuracy

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K07754
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kagawa University
• Principal Investigator: Kudomi Nobuyuki 香川大学, 医学部, 准教授 (20552045)
• Co-Investigator(Kenkyū-buntansha): 前田 幸人 香川大学, 医学部附属病院, 技術職員 (10763336) ; 山本 由佳 香川大学, 医学部, 准教授 (30335872) ; 西山 佳宏 香川大学, 医学部, 教授 (50263900) ; 畠山 哲宗 香川大学, 医学部, 助教 (90602805)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 酸素摂取率 / もやもや病 / 動静脈奇形 / PET

Outline of Final Research Achievements

Cerebral blood flow, oxygen extraction fraction (OEF) and metabolic rate images are essential for cerebro-vascular disorders and can be measured by PET with 15O-gas. However, for Moyamoya disease and arterio-venous malformation (AVM), there are artefact on OEF imagea. The study aims at developing a correction method for the artefact. There are struggle in blood vessel in Moyamoya and this was taken into accounted in input function. Same can be applied for AVM. Validity was tested on subjects, n=40 and 16 for Mayamoya and AVM. The accuracy in input function was tested in simulation. The generated images were reasonably corrected, namely, elevated values around large blood vessel were disappeared. Simulation showed the accuracy in input function was ± 1 s. The results showed the present method is of use for the targeted disease.

Free Research Field

核医学画像解析

Academic Significance and Societal Importance of the Research Achievements

脳虚血に対して、脳血流、酸素摂取率および酸素代謝量定量画像による診断が有効とされている。しかし、その診断が必要とされるもやもや病や動静脈奇形症例に対して、大血管領域で酸素摂取率の上昇が見られるという問題があり、診断精度の劣化が懸念された。この上昇に対してこれを補正法するを開発した。補正によって得られた画像は、大血管周辺領域においても、他の領域と同様の画素値が得られ、診断の精度を劣化する懸念を払拭したと考えられる。