Elucidation of the pathogenesis and establishment of diagnostic methods for Food protein-induced enterocolitis syndrome

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K07848
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Yamaguchi University
• Principal Investigator: Fukuda Ken 山口大学, 医学部附属病院, 医師(時間給) (80566646)
• Co-Investigator(Kenkyū-buntansha): 長谷川 俊史 山口大学, 大学院医学系研究科, 教授 (90314806) ; 脇口 宏之 山口大学, 大学院医学系研究科, 助教 (00716590) ; 安戸 裕貴 山口大学, 大学院医学系研究科, 講師 (70422285)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: IL-2 / 新生児・乳幼児消化管アレルギー

Outline of Final Research Achievements

We analyzed the cytokine profiles of neonatal and infant gastrointestinal allergy and differential diseases (viral enteritis, bacterial enteritis, and type 1 allergy). Serum IL-2 and IL-10 concentrations were significantly increased in patients with neonatal and infantile gastrointestinal allergy in the symptomatic state compared to the asymptomatic state. There were no significant differences in IL-4, IL-6, INF-γ, and TNF-α between the symptomatic and asymptomatic states.
In comparison with the differential diseases (viral enteritis, bacterial enteritis, and type 1 allergy), the serum IL-2 concentration in the neonates and infants with gastrointestinal allergy group was significantly increased compared with the differential disease group. There were no significant differences in IL-4, IL-6, INF-γ, and TNF-α compared with the differential disease group.

Free Research Field

アレルギー

Academic Significance and Societal Importance of the Research Achievements

消化器症状を呈する急性期の新生児・乳幼児消化管アレルギーにおいて他疾患と比して有意に血清IL-2濃度が上昇することを確認した.この結果は新生児・乳幼児消化管アレルギーの診断、病性判定のバイオマーカーとしてIL-2が有効である可能性を示唆する.