Multilayered Omics Approach for Diabetic Cardiomyopathy

2023 Fiscal Year Final Research Report

• Project/Area Number: 18K08024
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: National Cardiovascular Center Research Institute (2020-2023); Tohoku University (2018-2019)
• Principal Investigator: YASUHIKO SAKATA 国立研究開発法人国立循環器病研究センター, 病院, 部長 (90379206)
• Co-Investigator(Kenkyū-buntansha): 後岡 広太郎 東北大学, 大学病院, 特任准教授 (20598411) ; 宮田 敏 東北大学, 医学系研究科, 大学院非常勤講師 (60360343) ; 澤田 正二郎 東北大学, 大学病院, 講師 (60509420)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Keywords: Heart Failure / Diabetes / Omics analysis / Diabetic Cardiomyopathy

Outline of Final Research Achievements

Diabetic cardiomyopathy is a myocardial disorder that originates from metabolic abnormalities caused by diabetes. However, the mechanism of diabetic cardiomyopathy is unclear, and it is still difficult to approach the prevention and treatment of ischemic heart failure from the perspective of diabetes and metabolism. In this study, we performed omics analysis on cases of ischemic heart disease complicated with diabetes, and attempted to elucidate the pathogenesis mechanism of diabetic cardiomyopathy in ischemic heart disease. Fatty acids are the main components of biological lipids, and are involved in maintaining life, such as energy production and the formation of cell membranes. In this study, we demonstrated the possibility of free fatty acids as a prognostic predictor for the onset of cardiovascular events, including heart failure.

Free Research Field

Heart Failure, Omics Analysis

Academic Significance and Societal Importance of the Research Achievements

糖尿病性心筋障害は糖尿病による代謝異常により生じる心筋障害です。しかしながらこれまでその発生機序は明らかではありませんでした。そこで本研究では糖尿病を合併する虚血性心疾患症例においてオミックス解析を行い、虚血性心疾患における糖尿病性心筋障害の病態形成機序の解明を試みました。