The pathogenesis of dermatitis induced by IL-33

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K08284
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Hyogo Medical University
• Principal Investigator: Imai Yasutomo 兵庫医科大学, 医学部, 講師 (10529514)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: IL-33 / Scgb

Outline of Final Research Achievements

Interleukin-33 (IL-33) is a pro-inflammatory cytokine that induces allergy. We analyzed the gene clusters induced in the skin of IL-33Tg mice and found that the Scgb family of secreted proteins, which are similar to the major antigens of feline allergy, are highly expressed, and the expression of Scgb family genes in particular was found to be increased in keratinocytes. In human AD patients, Scgb family proteins were also found to be increased in the epidermis. In the future, it will be necessary to conduct functional analysis of the Scgb family.

Free Research Field

皮膚免疫学

Academic Significance and Societal Importance of the Research Achievements

申請者らはIL-33Tgマウス皮膚におけるmRNAのマイクロアレイデータをもとにクラスター分析、主成分分析を行い、皮疹の発症とともに特異的にScgb ファミリーの遺伝子が誘導されることを見いだした。ヒトScgbファミリーは主要なネコアレルギー抗原(major cat allergen)であるFel d1（CH2）と相同性が高い。つまり、Scgbファミリーは抗原として働く可能性が推測された。