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2020 Fiscal Year Final Research Report

Clinical burden of RNA methylation as a diagnostic and predictive marker for colitis-associated cancer.

Research Project

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Project/Area Number 18K08591
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55010:General surgery and pediatric surgery-related
Research InstitutionMie University

Principal Investigator

Inoue Yasuhiro  三重大学, 医学系研究科, 客員准教授 (20324535)

Co-Investigator(Kenkyū-buntansha) 問山 裕二  三重大学, 医学系研究科, 教授 (00422824)
奥川 喜永  三重大学, 医学部附属病院, 講師 (30555545)
藤川 裕之  三重大学, 医学部附属病院, 助教 (40616091)
荒木 俊光  三重大学, 医学系研究科, リサーチアソシエイト (70343217)
楠 正人  三重大学, 医学系研究科, 寄附講座大学教員 (50192026)
Project Period (FY) 2018-04-01 – 2021-03-31
Keywords潰瘍性大腸炎 / 大腸癌 / メチル化
Outline of Final Research Achievements

In this study, we conducted comprehensive methylation analysis using surgical specimens from sporadic colorectal cancer or ulcerative colitis-associated CRC, and successfully identified cancer-specific hypermethylated CpG site. Furthermore, we validated this CpG site using pyrosequencing, and showed that quantification of methylation levels using non-neoplastic rectal mucosa could identify high-risk UC patients for CRC.

Free Research Field

エピゲノム

Academic Significance and Societal Importance of the Research Achievements

今回、潰瘍性大腸炎における様々な部位の大腸粘膜におけるメチル化の程度を明らかにし、さらに内視鏡検査にて簡便に評価可能かつ肛門鏡で生検可能な直腸粘膜を用い、そのメチル化のField effect/cancerizationを用いた大腸全体の癌化の状況を判別する概念を確立することはこれまでにない新しいアプローチとなる。

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Published: 2022-01-27  

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