2021 Fiscal Year Final Research Report
A comprehensive research of acute stroke thrombectomy-related subarachnoid hemorrhage
Project/Area Number |
18K08936
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 56010:Neurosurgery-related
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2018-04-01 – 2022-03-31
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Keywords | 脳梗塞 / 脳主幹動脈閉塞 / 血栓回収療法 / くも膜下出血 |
Outline of Final Research Achievements |
Stroke thrombectomy has been established as a standard of care. In contrary, post-thrombectomy subarachnoid hemorrhages (SAH) have been observed which were not seen after medical treatment. This study found that post-thrombectomy SAH occurred in 7.2% of patients and was not associated with a favorable outcome. Post-thrombectomy SAH was positively associated with CT angiography and the puncture-to-reperfusion time and negatively associated with blood glucose levels and complete recanalization). In addition, although the rate of complete recanalization and the rate of a favorable outcome decreased year by year, there was no trend of rates of intracranial hemorrhage including SAH. The number of thrombectomied patients and the rate of favorable outcome did not decrease during the COVID-19 epidemic period (the year 2020) as well as no significant association was found between the COVID-19 period and the incidence of post-thrombectomy SAH.
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Free Research Field |
脳神経外科学
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Academic Significance and Societal Importance of the Research Achievements |
急性期脳主幹動脈閉塞に対する血栓回収療法後のくも膜下出血の発症率、転帰への影響、関連する因子を明らかにできた。加えて、血栓回収療法全体の治療実態およびコロナ禍の影響についても明らかにすることができた。本研究の成果は、当該治療の安全性の向上および診療体制の改善に寄与すると考えられる。
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