Prognosis prediction for cardiovascular disease using cardiopulmonary exercise testing (CPX) in cardiac rehabilitation program

2023 Fiscal Year Final Research Report

• Project/Area Number: 18K10806
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Fukuoka University
• Principal Investigator: Kitajima Ken 福岡大学, 医学部, 准教授 (70469378)
• Co-Investigator(Kenkyū-buntansha): 三浦 伸一郎 福岡大学, 医学部, 教授 (20343709) ; 朔 啓二郎 福岡大学, 医学部, 教授 (40183371)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Keywords: 高齢者心疾患 / 心腎保護効果 / 心肺運動負荷試験(CPX) / 高比重リポ蛋白(HDL)機能 / 抗動脈硬化作用 / 抗酸化作用 / 炎症性サイトカイン

Outline of Final Research Achievements

In this study, we used cardiopulmonary exercise testing (CPX) during cardiac and large vessel rehabilitation to examine prognostic predictors of cardiovascular disease, particularly in elderly people aged 65 years or older. We reported that cardiac rehabilitation (cardiac rehab) improved cardiac function and suppressed the rate of decline in renal function associated with aging in elderly patients with cardiac and large vessel disease undergoing outpatient cardiac rehab. Although further verification is required, it was suggested that improved exercise tolerance may be an indicator of improved prognosis.

Free Research Field

脂質代謝

Academic Significance and Societal Importance of the Research Achievements

高齢化社会での心不全が増加する心不全パンデミックを2030年に迎えるにあたり、効果的な対策となりうる心臓リハビリテーションを活用して行った基礎実験と臨床研究にまたがる研究であった。身体活動を適切に行い、健康寿命を延長させることが、少子高齢化時代の医療費抑制に役立つことができると考えられた。