2022 Fiscal Year Final Research Report

Sarcopenia and inflammatory biomarker in endstage kidney disease

Research Project

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Project/Area Number	18K11010
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 59040:Nutrition science and health science-related
Research Institution	University of Occupational and Environmental Health, Japan
Principal Investigator	Miyamoto Tetsu 産業医科大学, 大学病院, 准教授 (30611305)
Co-Investigator(Kenkyū-buntansha)	荻ノ沢泰司産業医科大学, 医学部, 講師 (20596720) 尾辻豊産業医科大学, 医学部, 教授 (30264427) 田村雅仁産業医科大学, 大学病院, 非常勤医師 (40330980) 園田信成産業医科大学, 医学部, 非常勤医師 (90299610)
Project Period (FY)	2018-04-01 – 2023-03-31
Keywords	サルコペニア / 低栄養 / GLIM基準 / AWGS2019 / 血液透析
Outline of Final Research Achievements	We conducted various physical measurements, body composition analysis, and blood sampling for　incident HD patients. Diagnosis of sarcopenia according to the AWGS criteria, the determination of malnutrition according to the GLIM criteria, and the nutritional risk screening using MIS, GNRI, and CONUT scoring were performed. We found that 27.9% had sarcopenia, 6% of which was severe and thirty-nine percent had malnutrition,12% of which was severe. When stratified by the presence or absence of sarcopenia or malnutrition, there were no significant differences in nutritional risk scoring. Using the protein array method , semi-quantitative serum concentrations of 120 inflammation-related proteins were performed in the collected serum samples. No significant differences in 120 inflammatory proteins between the patients with malnutrition or sarcopenia and the patients without malnutrition or sarcopenia have been detected. We plan to conduct additional studies in the future.
Free Research Field	Hemodialysis, Nutrition
Academic Significance and Societal Importance of the Research Achievements	現時点で透析導入時に栄養評価を行い、約３０％がサルコペニア、約４０％が低栄養状態にあることが明かかになった。これまではコンセンサスの得られた評価方法が無かったが、2019年に発表されたAWGS2019およびGLIM基準にて正確な栄養評価を行い、上記結果を得たことは意義がある。