Examination of nutritional factors related to diabetic nephropathy and/or retinopathy in patients enrolled from Kagoshima city CKD prevention network

2023 Fiscal Year Final Research Report

• Project/Area Number: 18K11038
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Kagoshima Prefectural College
• Principal Investigator: Arimura Emi 鹿児島県立短期大学, 生活科学科 食物栄養専攻, 准教授 (40552964)
• Co-Investigator(Kenkyū-buntansha): 西尾 善彦 鹿児島大学, 医歯学域医学系, 教授 (40281084) ; 堀内 正久 鹿児島大学, 医歯学域医学系, 教授 (50264403)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Keywords: 糖尿病腎症 / 糖尿病網膜症 / 食事療法 / 食事摂取頻度調査 / ヨウ素 / 脂質 / 異化 / 随時尿

Outline of Final Research Achievements

This study aimed to examine the risk factors, including nutritional status, for complications in patients newly diagnosed with T2DM. Fifty-four patients were recruited, to evaluate nutritional status, blood and urine examinations were performed and FFQ was administered.The patients were categorized into four groups: 24 without albuminuria and without retinopathy, four without albuminuria and with retinopathy, 21 with albuminuria and without retinopathy, and five with albuminuria and with retinopathy. Patients with retinopathy showed significantly higher blood urea nitrogen, and significantly lower plasma total protein than patients without retinopathy, suggesting that retinopathy is related to a higher catabolic state. Through the questionnaire on food intake, patients with retinopathy showed significantly lower intake of fat and monounsaturated fatty acids and significantly higher intake of iodine, corrected for energy intake, than patients without retinopathy.

Free Research Field

臨床栄養

Academic Significance and Societal Importance of the Research Achievements

新たに2型糖尿病と診断された患者の糖尿病合併症に関連する栄養状態を含む危険因子を検討することは、糖尿病合併症発症予防に有用な知見と思われた。