The effect of Poly (ethylene sodium phosphate) on bone strength and bone mineral density of femur in ovariectomized mice.

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K12045
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90110:Biomedical engineering-related
• Research Institution: Osaka Medical College
• Principal Investigator: Yokota Atsushi 大阪医科大学, 医学部, 講師 (10449564)
• Co-Investigator(Kenkyū-buntansha): 岩崎 泰彦 関西大学, 化学生命工学部, 教授 (90280990)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: ポリリン酸エステル / 骨粗鬆症 / 骨密度 / 卵巣摘出マウス

Outline of Final Research Achievements

To clarify the effect of newly-synthesized Poly (ethylene sodium phosphate), PEP・Na on bone strength and bone mineral density of femur, twelve-week-old ovariectomized (OVX) mice were administered multiple doses of PEP・Na (MPN group) every 4 weeks (total 3 doses). MPN mice were compared with OVX control mice (CTL group) by high-resolution peripheral quantitative computed tomography analyses at different time points to evaluate the BMD of the femur. In addition, biochemical examinations of the blood specimens were analyzed to assess the safety of PEP・Na administration. The increasing rate in BMD of MPN mice was significantly higher than that in the CTL group. Moreover, no adverse effects by PEP・Na administration were observed. These results indicate PEP・Na holds therapeutic potential for future application as treatment for osteoporosis.

Free Research Field

整形外科学

Academic Significance and Societal Importance of the Research Achievements

本邦では骨粗鬆患者の約８割が未治療とされており、治療普及率の低さが問題となっている。薬物治療の第一選択として広く使われているBP製剤や、モノクローナル抗体製剤であるロモソズマブには様々な副作用も報告されており、低い治療普及率の一因になっていると思われる。そこで本研究では、新規ポリリン酸エステルPEP・Naが骨密度、骨強度に与える影響を検討し、その骨密度上昇効果と安全性を動物モデルにて証明した。今後、詳細な薬理作用や安全性について更なる検討が必要であるが、PEP・Naが骨粗鬆患者にとってより安全、安価かつ有効性、利便性が高い新規治療薬になり得る可能性が示された。