The mechanisms of extracellular ion homeostasis by brain fluid dynamics

2019 Fiscal Year Final Research Report

• Project/Area Number: 18K14859
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 46030:Function of nervous system-related
• Research Institution: Ochanomizu University
• Principal Investigator: Monai Hiromu お茶の水女子大学, 基幹研究院, 助教 (90708413)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Keywords: 脳梗塞 / 脳脊髄液（髄液） / カリウムイオン / ノルアドレナリン / 阻害薬 / アストロサイト / アクアポリン4

Outline of Final Research Achievements

The cerebral spinal fluid (CSF) flow is as well disrupted by stroke. In this study, we found that the adrenergic receptor (AdR) blockade significantly reduced the infarct area. We also found that the AdR blockade maintains the expression of the brain water channel, aquaporin 4 (AQP4), which is involved in the CSF flow. The mechanisms of the AdR blockade may be the improvement of CSF flow and facilitation of normalization of extracellular potassium ion, due to the preservation of AQP4. We believe that CSF will play an essential role in protecting a healthy brain and maintaining a normal brain environment.

Free Research Field

神経生理学

Academic Significance and Societal Importance of the Research Achievements

髄液の流れは、健康な脳を守り、正常な脳環境を維持するのに重要な役割を果たしていると考えられます。私達の研究成果が今後、脳梗塞の治療法の開発に貢献していくことが期待されます。