Investigation of novel dose adjusting method for antibacterial drug using L-FABP

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K14946
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 47060:Clinical pharmacy-related
• Research Institution: Chiba University
• Principal Investigator: Suzuki Takaaki 千葉大学, 医学部附属病院, 准教授 (30396676)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: L-FABP / 腎障害 / バイオマーカー

Outline of Final Research Achievements

We investigated the possibility of clinical application of urinary L-FABP level as a candidate for renal function marker useful for drug therapy as an alternative to creatinine and cystatin C. This study suggests that vancomycin-induced nephropathy is likely to occur in patients with high L-FABP before drug administration, while teicoplanin-induced nephropathy may be less likely to occur even with high L-FABP. In some cases of vancomycin administration, C/D increased without fluctuation of serum creatinine, suggesting that the L-FABP level before administration may predict renal damage that cannot be detected by fluctuation of serum creatinine level.

Free Research Field

医療薬学

Academic Significance and Societal Importance of the Research Achievements

L-FABPは「尿細管機能障害を伴う腎疾患診断の補助」的な観点からの保険適応しかなく、バンコマイシンなどの腎排泄型薬物や腎障害を副作用に持つ薬物の副作用モニタリングおよび投与設計への尿中L-FABPの応用に関する検討は現在までなされていない。本研究により従来の腎機能指標であるクレアチニン値やシスタチンC値よりも早期に腎障害を予測できる可能性を見いだせた点で今後は薬物療法の安全性向上に応用が期待できる。