Regulation of dendritic cells and lymphoid tissues by CD47-SIRPalpha signaling

2019 Fiscal Year Final Research Report

• Project/Area Number: 18K15190
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49070:Immunology-related
• Research Institution: Kobe University
• Principal Investigator: Saito Yasuyuki 神戸大学, 医学研究科, 講師 (40508842)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Keywords: 樹状細胞 / ストローマ細胞 / 自己免疫疾患 / SIRPα / CD47

Outline of Final Research Achievements

We investigated the regulatory mechanism how dendritic cells (DCs) mediates lymphoid tissue reconstitution, as well as regulates the pathogenesis of autoimmune diseases, by the CD47-SIRPα signaling. We found that SIRPα signaling is important for DC-induced maintenance of stromal cells in vivo, as wll as for the reconstitution of lymphoid tissue. Furthermore, we found that SIRPα and CD47 on DCs regulate the priming of self-reactive T cells in the peripheral lymphoid tissue and the subsequent infiltration or reactivation of inflammatory cells into the central nervous system in an experimental autoimmune encephalomyelitis model.

Free Research Field

免疫学、血液学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により、自己免疫疾患の発症やリンパ組織ストローマ細胞の再構築において新たな作用機序の解明をもたらすことから、各種免疫疾患（自己免疫疾患、感染症、移植免疫）や腫瘍免疫応答に対する革新的な診断や治療技術開発などの新たな創造をもたらすことが期待される。