Protocol development for detecting tiny pancreatic cancer using hyperpolarized DNP-MRI

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K15312
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50020:Tumor diagnostics and therapeutics-related
• Research Institution: Gifu University
• Principal Investigator: Noda Yoshifumi 岐阜大学, 医学部附属病院, 助教 (60643020)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: MRI / 膵癌

Outline of Final Research Achievements

MIA PaCa-2 cells were subcutaneously administered to the right leg of mice. In vivo DNP-MRI were performed at pre, 1, 3, 7 days after irradiation. Decay rate was calculated by the change in DNP image intensity. Redox map was obtained by the slope of the enhanced DNP image intensity using a custom Excel macro program DNP-MRI scanning of right leg was started immediately after intravenous injection of nitroxyl contrast agent, CmP. Pharmacokinetic DNP-MRI images were performed at 0.5, 2, 4, 6, 8, 10, 14, 18, and 22 minutes after administration. Decay rate was significantly decreased at day 1 after irradiation compared to before irradiation. There was no change in tumor size even one week after irradiation.

Free Research Field

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Academic Significance and Societal Importance of the Research Achievements

今回の結果より、レドックス代謝をイメージングバイオマーカーとする本技術は膵癌の早期診断および治療効果の早期判別に有効であると考えられる。