2022 Fiscal Year Final Research Report
Characterization of subcortical structures in clinical high-risk state for psychosis using Japanese multicenter data toward clinical application
| Project/Area Number |
18K15509
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Keywords | 統合失調症 / 精神病発症危険状態 / 大脳皮質下領域体積 / 多施設共同研究 / 側性 / MRI / 早期介入 / 病態解明 |
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| Outline of Final Research Achievements |
We organized a Japanese multicenter study (University of Toyama, Toho University, Tohoku University, and University of Tokyo) and collected magnetic resonance imaging data from 107 individuals with at-risk mental state (ARMS) group and 104 healthy controls. Compared with the controls, ARMS group as a whole exhibited increased volume of the left lateral ventricle, left caudate nucleus, and left globus pallidus, and decresed volume in the right accumbens, possibly reflecting a general vulnerability to mental illness. These major findings were summarized and published as an original article in Schizophrenia Bulletin.
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| Free Research Field |
精神神経科学関連
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| Academic Significance and Societal Importance of the Research Achievements |
多数例のARMS 群を対象として発症に先立つ脳形態変化を検出することで、早期の補助診断(脳形態を用いた精神病性障害発症の予測)に寄与することが期待できる。また服薬や疾患経過の影響の少ない ARMS群を対象とすることで、精神病性障害における純粋な疾患過程を反映した所見が得られる可能性がある。その知見を基に動物モデルにおける大脳基底核を含む回路解析などの基礎研究が進むことにより、精神病性障害における脳内神経回路の異常の解明に繋がることが期待される。
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