Prediction and progression model of radiation induced lung injury

2021 Fiscal Year Final Research Report

• Project/Area Number: 18K15539
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Tohoku University
• Principal Investigator: Yamamoto Takaya 東北大学, 大学病院, 講師 (30733159)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: 体幹部定位放射線治療 / 放射線誘発肺障害 / 放射線肺臓炎

Outline of Final Research Achievements

Radiation-induced lung toxicity after lung stereotactic radiotheapy (SRT) was prospectively analyzed using pre-SRT, 1-month, 4-month and 12-month fullow-up examinations including CT, laboratory data and pulmonary function tests. Sixteen patients were analyzed. Mean HU and SD of whole lung, KL-6 and SP-D peaked at 4 months after SRT, in contrast, all items of pulmonary function tests declined as time went on and they showed the lowest value at 12-month examination. SP-D at 4 months, forced vital capacity and diffusion capacity for carbon monoxide at 12 months showed significant relationships with lung dose-volume parameters. Furthermore, change of HU in each irradiated dose bins showed dose dependent HU change.

Free Research Field

放射線腫瘍学

Academic Significance and Societal Importance of the Research Achievements

SRTにおける肺線量と呼吸機能との関連を詳細に調べた報告は希少で、特に肺拡散能力とSRTの肺線量の相関の報告は知りうる限り初の報告となる。これによりSRT後のより詳細な呼吸機能予測の一助となることが期待される。