Evaluation of hepatic DNA damage accumulation in trans-arterial chemoembolization using a monoclonal antibody to oxidatively generated DNA damage

2019 Fiscal Year Final Research Report

• Project/Area Number: 18K15598
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Nara Medical University
• Principal Investigator: Tatsumoto Shota 奈良県立医科大学, 医学部附属病院, 研究員 (50771854)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Keywords: 酸化的DNA損傷 / フリーラジカル / 血管内治療 / 磁気共鳴画像 / 骨盤

Outline of Final Research Achievements

Free radicals are deeply involved in the pathogenesis and exacerbation of various oxidative stress diseases. We used oxidative DNA-damage-specific antibodies to determine the presence or absence of DNA damage that can occur during transarterial chemoembolization. In addition,we examined the correlation between the capacity to produce hydroxyl radicals in endometriotic cysts and the progression of endometriosis as assessed by magnetic resonance imaging,providing useful basic information.

Free Research Field

放射線医学

Academic Significance and Societal Importance of the Research Achievements

血管内手技または医用画像と生体内レドックス代謝を関連付けた研究は殆ど行われていない。本研究では肝動脈塞栓術と子宮内膜症に焦点を当て、放射線医学の観点から生体内レドックス代謝との関連を検証し、基礎情報が取得できた。現在、基礎研究レベルで精力的に行われている酸化ストレスの画像診断が臨床応用された際に、今回の研究は重要な情報になると考える。