The radiation dose escalation study for limited-disease small-cell lung cancer

2021 Fiscal Year Final Research Report

• Project/Area Number: 18K15616
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Osaka International Cancer Institute
• Principal Investigator: Masahiro Morimoto 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 放射線腫瘍科副部長 (00745359)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: 放射線治療

Outline of Final Research Achievements

Three lung tumor cases are entered in this study. The aim of this study is a comparison of inspiratory breath holding system signal and real-time position management system signal at the radiation planning computed tomography. The three cases of the inspiratory breath holding system signal and real-time position management system signal ±standard deviation(%) are ±4, ±3, ±1 and ±13, ±6, ±7, respectively. The three cases planning target volume of the virtual radiation planning at inspiratory breath holding system are 1.5 cc lower than those of the actual radiation planning of real-time position management system. Then, lung V20 and V5 are 1.2% and 2.7% lower in virtual radiation planning at inspiratory breath holding system than those of actual radiation planning of real-time position management system. The signal of inspiratory breath holding system is more stable than that of real-time position management system.

Free Research Field

放射線治療

Academic Significance and Societal Importance of the Research Achievements

学術的意義は、肺腫瘍の放射線治療に関して、吸気実測息止めシステムの信号波形が、従来の腹壁に置いた赤外線マーカーの信号波形に比べて安定していて、治療計画CTに使用可能である。照射体積を減らし、正常組織に当たる放射線の量を減らせる。社会的意義は、臨床応用ができれば、患者の放射線治療による有害事象を減らすことができる。照射体積を減らすことによって、腫瘍内を、今までより正確に線量増加できる可能性がでてくる。