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2019 Fiscal Year Final Research Report

Evaluation of cytoprotective effect of autophagy and its application for novel cancer therapy

Research Project

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Project/Area Number 18K15653
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionHokkaido University

Principal Investigator

Suzuki Motofumi  北海道大学, 薬学研究院, 助教 (90807801)

Project Period (FY) 2018-04-01 – 2020-03-31
Keywordsオートファジー / 細胞周期チェックポイント / 放射線治療 / 放射線増感剤
Outline of Final Research Achievements

A better mechanistic understanding of cellular resistance to radiotherapy should facilitate the development of novel, individualized treatment approaches. Cell-cycle checkpoint and autophagy act in concert to confer radioresistance to cells. In this study, I investigated the functional interaction between both pathways. As a result, I revealed as follows; (1) X-irradiation synchronously induced autophagy and G2 checkpoint. (2) Radiation-induced autophagy produced the ATP required for cell survival. (3) A biological crosstalk exists between G2 checkpoint and autophagy after X-irradiation, and autophagy appears to be responsible, at least in part, for G2 checkpoint-induced radioresistance.

Free Research Field

放射線生物学

Academic Significance and Societal Importance of the Research Achievements

本研究では核内で生じる細胞周期チェックポイントと細胞質で生じるオートファジーという異なる細胞防護機構にクロストークが存在することを明らかにした。本研究により得られた知見はこれまで明らかとなっていなかったオートファジーによる細胞防護機構の機序解明につながる。また、がん細胞の有する放射線抵抗性の機序解明に大きく寄与するものであり、今後の放射線治療増感剤の開発や治療プロトコルの作成において新たな指標となり得ることが期待される。

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Published: 2021-02-19  

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