Pathological significance of myocardial infiltrating inflammatory cells in patients with dilated cardiomyaopathy

2023 Fiscal Year Final Research Report

• Project/Area Number: 18K15855
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Nagoya City University
• Principal Investigator: Nakayama Takafumi 名古屋市立大学, 医薬学総合研究院(医学), 研究員 (00791154)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Keywords: 心筋生検 / リンパ球 / マクロファージ / 樹状細胞 / 炎症細胞浸潤 / 拡張型心筋症

Outline of Final Research Achievements

We analyzed the relationships between infiltrating inflammatory cells and clinical features in patients diagnosed with dilated cardiomyopathy clinically.
Among 128 patients who underwent myocardial biopsy, we obtained clinical data and pathological counts of T lymphocytes, B lymphocytes, macrophages, dendritic cells, regulatory T cells, and MHC. However, no significant relationship between clinical data and pathological results has been found. We believe the variety of diagnoses of dilated cardiomyopathy, the conditions, and artifacts of pathological specimen preparation were one of the problems. We are discussing this topic further with the other researchers outside; then we want to report the results after the fund period.

Free Research Field

心筋症

Academic Significance and Societal Importance of the Research Achievements

拡張型心筋症における慢性心筋内炎症細胞浸潤は、予後予測や病態理解において近年注目されている。本研究で得た臨床データと検体データ、もしくは非有意な結果となった原因を更に検証し、今後の自施設、他施設、両者における研究計画・遂行に役立てたい。