Adipose (pro)renin receptor and multiple organ damage in metabolic syndrome

2021 Fiscal Year Final Research Report

• Project/Area Number: 18K16212
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Seki Yasufumi 東京女子医科大学, 医学部, 助教 (20649488)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: 肥満 / レニン-アンジオテンシン系 / プロレニン

Outline of Final Research Achievements

We investigated the role of adipose (pro)renin receptor [(P)RR] on tissue renin-angiotensin system and fat disposition in growth hormone deficiency, which cause visceral obesity. Serum (P)RR level was increased in obese mice and growth hormone deficiency by growth hormone receptor antagonist increased adipose (P)RR expression. In addition, (P)RR expression in subcutaneous fat was also increased in GH-deficient patients and significantly correlated with IGF-1 SD score. Adipose (P)RR expression might be increased in GH deficiency and contribute to activation of tissue renin-angiotensin system.

Free Research Field

内分泌学

Academic Significance and Societal Importance of the Research Achievements

欧米型食生活や運動不足は内臓脂肪の蓄積を介してメタボリック症候群を引き起こし、高血圧、糖尿病、脂質異常症を介して死亡率上昇やQOL低下につながる。成長ホルモン分泌不全症は内臓脂肪蓄積型肥満を引き起こし、重篤な合併症を呈する。本研究成果から脂肪組織(P)RRを介したメタボリック症候群における新たな臓器障害の機序の解明に応用できる可能性がある。