Elucidation of the regulation mechanism of gene expression related to platelet dysfunction in cardiac surgery with cardiopulmonary bypass

2019 Fiscal Year Final Research Report

• Project/Area Number: 18K16457
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Ishii Sachiyo 京都府立医科大学, 医学(系)研究科(研究院), 助教 (40457958)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Keywords: 血小板 / microRNA

Outline of Final Research Achievements

In cardiovascular surgeries undergoing with cardiopulmonary bypass (CPB), it has been shown that platelet activity is temporarily reduced after weaning from CPB, which is one cause of postoperative bleeding.However,the molecular biological mechanisms are still largely unknown. In this study, we conducted research based on the hypothesis that small RNA called microRNA is associated with platelet dysfunction after CPB.
As a result, it was suggested that the expression of some microRNAs in platelets after CPB up-regulated and this may cause the down-regulation of the expression of platelet membrane proteins related to hemostasis.

Free Research Field

血小板

Academic Significance and Societal Importance of the Research Achievements

人工心肺離脱後の血小板機能低下の分子生物学的なメカニズムがmicroRNAレベルで引き起こされている可能性を示唆したことが本研究の学術的意義であると考えられる。また、本研究の社会的意義として、それらのmicroRNAをターゲットにした治療法に展開できる可能性を有していることが挙げられる。