Development of a novel treatment for medication-related osteonecrosis of the jaw using zinc ions

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K17216
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Yamagata University
• Principal Investigator: Hemmi Tomoharu 山形大学, 医学部, 客員研究員 (60811924)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 薬剤関連顎骨壊死 / 歯肉線維芽細胞 / ビスホスホネート系製剤 / 機械的ストレス

Outline of Final Research Achievements

The pathogenesis of medication-related osteonecrosis of the jaw is unknown. In order to develop new treatments for the disease It is essential to elucidate the pathogenesis of it. In the present study, we investigated the effects of bisphosphonates and mechanical stress on gingival fibroblasts. As a result, it was confirmed that the disruptive effects of bisphosphonates on gingival fibroblasts were amplified by mechanical stress. This suggests that mechanical stress may be a factor in the organ-specific development of medication-related osteonecrosis of the jaw.

Free Research Field

薬剤関連顎骨壊死

Academic Significance and Societal Importance of the Research Achievements

本研究はビスホスホネート系製剤および機械的ストレスが歯肉線維芽細胞に与える影響を調査することで、薬剤関連顎骨壊死の発症メカニズムを探ることを目的とした。有効な治療法が確立されていない同疾患の発症メカニズムを調査することは新規治療法の検討に繋がり、ひいては疾患で苦しむ患者への利益となりえる。