Elucidation and Application of Periostin-mediated Recovery Mechanism of Periodontal Tissue in Occlusal Hypofunctional Teeth

2023 Fiscal Year Final Research Report

• Project/Area Number: 18K17247
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Usumi-Fujita Risa 東京医科歯科大学, 東京医科歯科大学病院, 助教 (90706946)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Keywords: ペリオスチン / スプライシングバリアント / 軟骨形成 / 歯科矯正

Outline of Final Research Achievements

The role of each variant in cartilage formation and osteogenesis in the craniofacial region is summarized in the paper. Specifically, C56BL6 / N mice were used as the control group, as well as mice of each variant type, and the effects of each variant were measured morphologically and histologically; Micro-CT imaging showed that ΔEx17, ΔEx21, and ΔEx17&21 craniofacial bones, particularly in the mandible, were smaller values were observed, focusing on the mandibular head, indicating that the lack of Ex17 or Ex21 in periostin tends to lead to inadequate chondrocyte differentiation, resulting in smaller craniofacial bones.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

ペリオスチンの各スプライシングバリアントの役割について検討した顎顔面領域の研究は皆無である。特に軟骨細胞肥大に重要な役割を果たし、exon17については軟骨形成、骨形成の抑制につながっている可能性が示唆された。