Development of scar suppression method applying TGF-beta inhibitory effects of microfiber-associated protein MAGP-1

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K17275
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Fukuoka Dental College
• Principal Investigator: Fujita Takahiro 福岡歯科大学, 口腔歯学部, 助教 (30781421)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 歯科矯正学 / 口蓋裂手術 / 瘢痕 / 予防 / MAGP-1 / コラーゲン / TGF-β1 / 線維芽細胞

Outline of Final Research Achievements

Formation of scars after treatment for cleft palate surgery is a big problem. The main factor of scarring is that the fibroblasts at the surgical site produce large amounts of collagen. TGF-β promotes Collagen production. Therefore, we focused on the binding of TGF-β to the elastic fiber component MAGP-1. It was found that cultured fibroblasts increased TGF-β1 and MAGP-1 mRNA expression with tension, and that MAGP-1 and TGFβ-1 coexisted as a complex. MAGP-1 may capture TGF-β and prevent it from binding to cells, and administration of MAGP-1 to cleft palate surgical wounds may be useful as an approach to prevent scarring.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

口蓋裂手術創傷へのMAGP-1の注射投与を考えています。MAGP-1の注射投与が瘢痕を予防するためのアプローチとして確立されれば、口蓋裂手術創傷後の瘢痕による歯列狭窄、またそれを防止するための手術や治療から、患者さんを解放する大きなメリットがあります。患者さんへの装置のセットを必要とせずに、定期的に注射をするだけで良いので負担が少なく、確立されると社会的歯科医学的に大きく普及されると予想されます。