Evaluation of pharmacological activity of new cannabinoids systematically synthesized and these metabolites or decompositions

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K17364
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: Osaka Institute of Public Health
• Principal Investigator: Asada Akiko 地方独立行政法人 大阪健康安全基盤研究所, 衛生化学部, 研究員 (80622753)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 危険ドラッグ

Outline of Final Research Achievements

Designer drug is a serious social problem in recent years. This study aimed to evaluate the pharmacological activity of new synthetic cannabinoids systematically synthesized.
As a result, we synthesized 35 new synthetic cannabinoids and evaluated their activities as CB1 and CB2 cannabinoid receptor agonists. In addition, we clarified the decomposition of the synthetic cannabinoid by heating and evaluated its activity as agonist.

Free Research Field

分析化学

Academic Significance and Societal Importance of the Research Achievements

危険ドラッグについての最も大きな問題のひとつは、部分構造をわずかに改変した薬物が次々と出回るため、関連する研究が常に後追い状態となり、薬物の危険性について情報が不足する状況が起こりやすいことである。本研究は新規合成カンナビノイド系薬物の危険性を推定する上で重要な受容体活性化能を明らかにすることに加え、分解物と考えられる化合物の活性化能を含めて評価することで、化合物自体の活性化能と実際の薬物摂取時の作用について差が生じる可能性を示した。