To redefine blood-brain-barrier (BBB)

2020 Fiscal Year Annual Research Report

• Project/Area Number: 18K19510
• Research Institution: Nagoya University
• Principal Investigator: 長縄 慎二 名古屋大学, 医学系研究科, 教授 (50242863)
• Co-Investigator(Kenkyū-buntansha): 田岡 俊昭 名古屋大学, 医学系研究科, 特任教授 (30305734)
• Project Period (FY): 2018-06-29 – 2021-03-31
• Keywords: 血液脳関門 / ガドリニウム造影剤 / 磁気共鳴画像 / 血液迷路関門

Outline of Annual Research Achievements

今回の研究課題の目的である「血液脳関門透過性の再定義に向けて」を進めるために、近年、我々が開発した液体中の極微量のガドリニウム造影剤への感度をさらに高めるための新規パルスシーケンスとともに、さらにdeep learning reconstruction(DLR)によるノイズ低減技術の併用することで、コントラストノイズ比を飛躍的に上昇させた手法を用いて、臨床応用を進めた。本研究で開発したパルスシーケンスパラメーターの最適化の繰り返し時間の延長と反転時間の最適化、フリップアングルの増加などを施行しつつ、improved-HYDROPS(i-HYDROPS)法とi-HYDROPSの技術も応用した。さらに我々が以前に開発したHYDROPS2-Mi2法での検討も行った。造影後のParadoxycal signal decreaseを防ぐための3D-real IR法も用いて、臨床例で脳のGlymphatic systemの評価のために上矢状洞近傍で脳表の皮質静脈周囲の嚢胞形成が、静脈周囲くも膜下腔へのガドリニウム造影剤漏出と関連していることを世界で初めて見出した。嚢胞が年齢とともに増大していくこと、嚢胞にも造影効果があること、血液脳脊髄液関門の状況によって嚢胞の造影効果も変化することなどを示した。静脈周囲軟膜膜下腔からくも膜下腔への造影剤の漏出が、症例を増やしても以前初期報告を行ったとおり37歳から増加することを改めて示した。これらの結果は世界から注目されており、国際脳血管病学会などで招待講演を行った。

Research Products

• [Journal Article] Relationship between Time-dependent Signal Changes in Parasagittal Perivenous Cysts and Leakage of Gadolinium-based Contrast Agents into the Subarachnoid Space. (2021)
  • Author(s): Shinji Naganawa, Rintaro Ito, Rei Nakamichi, Mariko Kawamura, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone.
  • Journal Title: Magn Reson Med Sci. Volume: - Pages: -
  • DOI: 10.2463/mrms.mp.2020-0138.
  • Peer Reviewed / Open Access
• [Journal Article] Age-related changes in the distribution of intravenously administered gadolinium-based contrast agents leaked into the cerebrospinal fluid in patients with suspected endolymphatic hydrops (2021)
  • Author(s): Toshio Ohashi, Shinji Naganawa, Saeko Iwata, Kayao Kuno
  • Journal Title: Jpn J Radiol. Volume: - Pages: -
  • DOI: 10.1007/s11604-020-01079-0.
  • Peer Reviewed / Open Access
• [Journal Article] Intracranial Distribution of Intravenously Administered Gadolinium-based Contrast Agent over a Period of 24 Hours: Evaluation with 3D-real IR Imaging and MR Fingerprinting. (2021)
  • Author(s): Shinji Naganawa,, Rintaro Ito, Yutaka Kato , Hisashi Kawai , Toshiaki Taoka, Tadao Yoshida, Katsuya Maruyama, Katsutoshi Murata , Gregor Korzdorfer , Josef Pfeuffer, Mathias Nittka , Michihiko Sone
  • Journal Title: Magn Reson Med Sci . Volume: 20(1) Pages: 91-98
  • DOI: 10.2463/mrms.mp.2020-0030.
  • Peer Reviewed / Open Access
• [Journal Article] Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics. (2021)
  • Author(s): Toshiaki Taoka, Shinji Naganawa
  • Journal Title: Jpn J Radiol. Volume: 39(1) Pages: 1-14
  • DOI: 10.1007/s11604-020-01017-0.
  • Peer Reviewed / Open Access
• [Journal Article] Diffusion analysis of fluid dynamics with incremental setength of motion proving gradient (DANDYISM) to evaluate cerebrospinal fluid dynamics (2021)
  • Author(s): Toshiaki Taoka, Hisashi Kawai, Toshiki Nakane, Takashi Abe, Rei Nakamichi, Rintaro Ito, Yuki Sato, Mayuko Sakai, Shinji Naganawa
  • Journal Title: Japanese Journal of Radiology. Volume: 39(4) Pages: 315-323
  • DOI: 10.1007/s11604-020-01075-4.
  • Peer Reviewed / Open Access
• [Journal Article] Evaluating the Effect of Arterial Pulsation on Cerebrospinal Fluid Motion in the Sylvian Fissure of Patients with Middle Cerebral Artery Occlusion Using Low b-value Diffusion-weighted Imaging. (2021)
  • Author(s): Toshiaki Taoka, Hisashi Kawai, Toshiki Nakane, Takashi Abe, Rei Nakamichi, Rintaro Ito, Yutaro Sasaki, Ayumi Nishida, Shinji Naganawa
  • Journal Title: Magn Reson Med Sci. Volume: - Pages: -
  • DOI: 10.2463/mrms.mp.2020-0121.
  • Peer Reviewed / Open Access
• [Journal Article] Iodine-related attenuation in contrast-enhanced dual-energy computed tomography in small-sized solid-type lung cancers is associated with the postoperative prognosis (2021)
  • Author(s): Shingo Iwano, Shinichiro Kamiya, Rintaro Ito, Shota Nakamura, Shinji Naganawa
  • Journal Title: Cancer Imaging . Volume: 21(1) Pages: 7
  • DOI: 10.1186/s40644-020-00368-1.
  • Peer Reviewed / Open Access
• [Journal Article] Time-resolved 3D cine phase-contrast magnetic resonance imaging (4D-flow MRI) can quantitatively assess portosystemic shunt severity and confirm normalization of portal flow after embolization of large portosystemic shunts (2021)
  • Author(s): Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Yoji Ishizu, Masataka Sugiyama, Shinji Naganawa
  • Journal Title: Hepatol Res . Volume: 51(3) Pages: 343-349
  • DOI: 10.1111/hepr.13616.
  • Peer Reviewed / Open Access
• [Journal Article] Dilatation of the Endolymphatic Space in the Ampulla of the Posterior Semicircular Canal: A New Clinical Finding Detected on Magnetic Resonance Imaging (2021)
  • Author(s): Masaru Morioka, Satofumi Sugimoto, Tadao Yoshida, Masaaki Teranishi, Masumi Kobayashi, Naoki Nishio, Naomi Katayama, Shinji Naganawa, Michihiko Sone
  • Journal Title: Otol Neurotol. Volume: - Pages: -
  • DOI: 10.1097/MAO.0000000000003073.
  • Peer Reviewed / Open Access
• [Journal Article] Lesion-specific prognosis by magnetic resonance imaging in sudden sensorineural hearing loss (2021)
  • Author(s): Cheng-Jui Yang, Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Masumi Kobayashi, Naoki Nishio, Shinji Naganawa, Michihiko Sone
  • Journal Title: Acta Otolaryngol. Volume: 141(1) Pages: 5-9
  • DOI: 10.1080/00016489.2020.1827159.
  • Peer Reviewed / Open Access
• [Journal Article] The Glymphatic System: A Review of the Challenges in Visualizing its Structure and Function with MR Imaging (2020)
  • Author(s): Shinji Naganawa, Toshiaki Taoka
  • Journal Title: Magn Reson Med Sci. Volume: - Pages: -
  • DOI: 10.2463/mrms.rev.2020-0122.
  • Peer Reviewed / Open Access
• [Journal Article] Neurofluid Dynamics and the Glymphatic System: A Neuroimaging Perspective (2020)
  • Author(s): Toshiaki Taoka, Shinji Naganawa
  • Journal Title: Korean J Radiol . Volume: 21(11) Pages: 1199-1209
  • DOI: 10.3348/kjr.2020.0042.
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between Parasagittal Perivenous Cysts and Leakage of Gadolinium- based Contrast Agents into the Subarachnoid Space around the Cortical Veins after Intravenous Administration. (2020)
  • Author(s): Shinji Naganawa, Rintaro Ito, Rei Nakamichi, Mariko Kawamura, Hisashi Kawai, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone
  • Journal Title: Magn Reson Med Sci . Volume: - Pages: -
  • DOI: 10.2463/mrms.mp.2020-0062.
  • Peer Reviewed / Open Access
• [Journal Article] Detection of IV-gadolinium Leakage from the Cortical Veins into the CSF Using MR Fingerprinting. (2020)
  • Author(s): Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Hirokazu Kawaguchi, Katsuya Maruyama, Katsutoshi Murata, Gregor Korzdorfer, Josef Pfeuffer, Mathias Nittka, Michihiko Sone
  • Journal Title: Magn Reson Med Sci. Volume: 19(2) Pages: 141-146
  • DOI: 10.2463/mrms.mp.2019-0048.
  • Peer Reviewed / Open Access
• [Journal Article] Confirmation of Age-dependence in the Leakage of Contrast Medium around the Cortical Veins into Cerebrospinal Fluid after Intravenous Administration of Gadolinium-based Contrast Agent (2020)
  • Author(s): Shinji Naganawa, Rintaro Ito, Hisashi Kawai, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone
  • Journal Title: Magn Reson Med Sci . Volume: 19(4) Pages: 375-381
  • DOI: 10.2463/mrms.mp.2019-0182.
  • Peer Reviewed / Open Access
• [Journal Article] MR Imaging of Endolymphatic Hydrops: Utility of iHYDROPS-Mi2 Combined with Deep Learning Reconstruction Denoising. (2020)
  • Author(s): Shinji Naganawa, Rei Nakamichi, Kazushige Ichikawa, Mariko Kawamura, Hisashi Kawai, Tadao Yoshida, Michihiko Sone
  • Journal Title: Magn Reson Med Sci . Volume: - Pages: -
  • DOI: 10.2463/mrms.mp.2020-0082.
  • Peer Reviewed / Open Access
• [Journal Article] A review on the use of artificial intelligence for medical imaging of the lungs of patients with coronavirus disease 2019 (2020)
  • Author(s): Rintaro Ito, Shingo Iwano, Shinji Naganawa
  • Journal Title: Diagn Interv Radiol . Volume: 26(5) Pages: 443-448
  • DOI: 10.5152/dir.2019.20294.
  • Peer Reviewed / Open Access
• [Journal Article] Abnormal Flow Dynamics Result in Low Wall Shear Stress and High Oscillatory Shear Index in Abdominal Aortic Dilatation: Initial in vivo Assessment with 4D-flow MRI (2020)
  • Author(s): Yasuo Takehara, Haruo Isoda, Mamoru Takahashi, Naoki Unno, Norihiko Shiiya, Takasuke Ushio, Satoshi Goshima, Shinji Naganawa , Marcus Alley, Tetsuya Wakayama, Atsushi Nozaki
  • Journal Title: Magn Reson Med Sci . Volume: 19(3) Pages: 235-246
  • DOI: 10.2463/mrms.mp.2019-0188.
  • Peer Reviewed / Open Access
• [Journal Article] Unexpected radioactive iodine accumulation on whole-body scan after I-131 ablation therapy for differentiated thyroid cancer (2020)
  • Author(s): Shingo Iwano, Shinji Ito, Shinichiro Kamiya, Rintaro Ito, Katsuhiko Kato, Shinji Naganawa
  • Journal Title: Nagoya J Med Sci . Volume: 82(2) Pages: 205-215
  • DOI: 10.18999/nagjms.82.2.205.
  • Peer Reviewed / Open Access
• [Journal Article] A phase I/II trial of intraoperative breast radiotherapy in an Asian population: 10-year results with critical evaluation. (2020)
  • Author(s): Mariko Kawamura, Yoshiyuki Itoh, Takeshi Kamomae, Masataka Sawaki, Toyone Kikumori, Nobuyuki Tsunoda, Junji Ito, Yoshie Shimoyama, Hiroko Satake, Shinji Naganawa
  • Journal Title: J Radiat Res . Volume: 61(4) Pages: 602-607
  • DOI: 10.1093/jrr/rraa029.
  • Peer Reviewed / Open Access
• [Journal Article] A case of stent-graft implantation for postpancreaticoduodenectomy hemorrhage in a patient with a reconstructed gastric tube. (2020)
  • Author(s): Tomohiro Komada, Yasushi Tachi, Ken Nagasaka, Suguru Yamada, Masaya Matsushima, Yutaro Sasaki, Shinji Naganawa
  • Journal Title: Radiol Case Rep . Volume: 15(12) Pages: 2710-2713
  • DOI: 10.1016/j.radcr.2020.10.021.
  • Peer Reviewed / Open Access
• [Journal Article] Portal Vein Stenosis Following Liver Transplantation Hemodynamically Assessed with 4D-flow MRI before and after Portal Vein Stenting. (2020)
  • Author(s): Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Yasuhiro Ogura , Shinji Naganawa
  • Journal Title: Magn Reson Med Sci . Volume: - Pages: -
  • DOI: 10.2463/mrms.ici.2020-0057.
  • Peer Reviewed / Open Access
• [Journal Article] Optimal Plane Selection for Measuring Post-prandial Blood Flow Increase within the Superior Mesenteric Artery: Analysis Using 4D Flow and Computational Fluid Dynamics (2020)
  • Author(s): Masataka Sugiyama, Yasuo Takehara, Masanori Kawate, Naoki Ooishi, Masaki Terada, Haruo Isoda, Harumi Sakahara, Shinji Naganawa, Kevin M Johnson, Oliver Wieben, Tetsuya Wakayama, Atsushi Nozaki, Hiroyuki Kabasawa
  • Journal Title: Magn Reson Med Sci. Volume: 19(4) Pages: 366-374
  • DOI: 10.2463/mrms.mp.2019-0089.
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive Evaluation of B1 +-corrected FISP-based Magnetic Resonance Fingerprinting: Accuracy, Repeatability and Reproducibility of T1 and T2 Relaxation Times for ISMRM/NIST System Phantom and Volunteers. (2020)
  • Author(s): Yutaka Kato, Kazushige Ichikawa, Kuniyasu Okudaira, Toshiaki Taoka, Hirokazu Kawaguchi, Katsutoshi Murata, Katsuya Maruyama, Gregor Koerzdoerfer, Josef Pfeuffer, Mathias Nittka, Shinji Naganawa
  • Journal Title: Magn Reson Med Sci. Volume: 19(3) Pages: 168-175
  • DOI: 10.2463/mrms.mp.2019-0016.
  • Peer Reviewed / Open Access
• [Journal Article] Quantification of Endolymphatic Space Volume after Intravenous Administration of a Single Dose of Gadolinium-based Contrast Agent: 3D-real Inversion Recovery versus HYDROPS-Mi2. (2020)
  • Author(s): Toshio Ohashi, Shinji Naganawa, Ai Takeuchi, Toshio Katagiri, Kayao Kuno
  • Journal Title: Magn Reson Med Sci. Volume: 19(2) Pages: 119-124
  • DOI: 10.2463/mrms.mp.2019-0013.
  • Peer Reviewed / Open Access
• [Journal Article] Change of White Matter Integrity in Children With Hematopoietic Stem Cell Transplantation. (2020)
  • Author(s): Yoko Sakaguchi, Jun Natsume, Hiroyuki Kidokoro, Masaharu Tanaka, Yu Okai, Yuji Ito, Hiroyuki Yamamoto, Atsuko Ohno, Tomohiko Nakata, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Hideki Muramatsu, Shinji Naganawa, Yoshiyuki Takahashi
  • Journal Title: Pediatr Neurol. Volume: 111 Pages: 78-84
  • DOI: 10.1016/j.pediatrneurol.2020.06.008.
  • Peer Reviewed / Open Access
• [Journal Article] Effects of endolymphatic hydrops on acoustic energy absorbance. (2020)
  • Author(s): Masumi Kobayashi, Tadao Yoshida, Satofumi Sugimoto, Mariko Shimono, Masaaki Teranishi, Shinji Naganawa, Michihiko Sone
  • Journal Title: Acta Otolaryngol . Volume: 140(8) Pages: 626-631
  • DOI: 10.1080/00016489.2020.1754460.
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of Severity in Chronic Thromboembolic Pulmonary Hypertension by Quantitative Parameters of Dual-Energy Computed Tomography. (2020)
  • Author(s): Tsutsumi Yoshinori, Iwano Shingo, Okumura Naoki, Adachi Shiro, Abe Shinji, Kondo Takahisa, Kato Katsuhiko, Naganawa Shinji
  • Journal Title: J Comput Assist Tomogr . Volume: 44(4) Pages: 578-585
  • DOI: 10.1097/RCT.0000000000001052.
  • Peer Reviewed / Open Access
• [Journal Article] Identifying the brain's connector hubs at the voxel level using functional connectivity overlap ratio. (2020)
  • Author(s): Bagarinao Epifanio, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Reiko Ohdake, Michihito Masuda, Aya Ogura, Toshiyasu Kato, Shuji Koyama, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue
  • Journal Title: Neuroimage . Volume: 222 Pages: 117241-117241
  • DOI: 10.1016/j.neuroimage.2020.117241.
  • Peer Reviewed / Open Access
• [Journal Article] Changes in white matter fiber density and morphology across the adult lifespan: A cross-sectional fixel-based analysis. (2020)
  • Author(s): Shao Wei Choy, Epifanio Bagarinao, Hirohisa Watanabe, Eric Tatt Wei Ho, Satoshi Maesawa, Noritaka Yoneyama, Kazunori Imai, Michihito Masuda, Toshiaki Taoka, Shuji Koyama, Hiroki C Tanabe, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue
  • Journal Title: Hum Brain Mapp . Volume: 41(12) Pages: 3198-3211
  • DOI: 10.1002/hbm.25008.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy and safety of accelerated fractionated radiotherapy without elective nodal irradiation for T3N0 glottic cancer without vocal cord fixation. (2020)
  • Author(s): Masayuki Okumura, Atsushi Motegi, Sadamoto Zenda, Naoki Nakamura, Hidehiro Hojo, Masaki Nakamura, Yasuhiro Hirano, Shun-Ichiro Kageyama, Satoko Arahira, Raturi Vijay Parshuram, Hirofumi Kuno, Ryuichi Hayashi, Makoto Tahara, Yoshiyuki Itoh, Shinji Naganawa, Tetsuo Akimoto
  • Journal Title: Head Neck . Volume: 42(8) Pages: 1775-1782
  • DOI: 10.1002/hed.26092.
  • Peer Reviewed / Open Access
• [Journal Article] Distribution of Gadolinium-based Contrast Agent after Leaking into the Cerebrospinal Fluid: Comparison between the Cerebral Cisterns and the Lateral Ventricles. (2020)
  • Author(s): Toshio Ohashi, Shinji Naganawa, Saeko Iwata, Kayao Kuno
  • Journal Title: Magn Reson Med Sci . Volume: - Pages: -
  • DOI: 10.2463/mrms.mp.2020-0016.
  • Peer Reviewed / Open Access
• [Journal Article] Significance of high signal intensity in the endolymphatic duct on magnetic resonance imaging in ears with otological disorders. (2020)
  • Author(s): Kyoko Morimoto, Tadao Yoshida, Masumi Kobayashi, Satofumi Sugimoto, Naoki Nishio, Masaaki Teranishi, Shinji Naganawa, Michihiko Sone
  • Journal Title: Acta Otolaryngol. Volume: 140(40) Pages: 818-822
  • DOI: 10.1080/00016489.2020.1781927.
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of segment 4 portal vein embolization added to right portal vein for right hepatic trisectionectomy: A retrospective propensity score-matched study. (2020)
  • Author(s): Jun Ito, Tomohiro Komada, Kojiro Suzuki, Masaya Matsushima, Masahiro Nakatochi, Yumiko Kobayashi, Tomoki Ebata, Shinji Naganawa, Masato Nagino
  • Journal Title: J Hepatobiliary Pancreat Sci . Volume: 27(6) Pages: 299-306
  • DOI: 10.1002/jhbp.723.
  • Peer Reviewed / Open Access
• [Journal Article] Aging Impacts the Overall Connectivity Strength of Regions Critical for Information Transfer Among Brain Networks. (2020)
  • Author(s): Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Toshiaki Taoka, Shuji Koyama, Hiroki C. Tanabe, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue
  • Journal Title: Front Aging Neurosci. Volume: 12 Pages: 592469-592469
  • DOI: 10.3389/fnagi.2020.592469.
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Head Motion on the Evaluation of Age-related Brain Network Changes Using Resting State Functional MRI. (2020)
  • Author(s): Sanae Kato, Epifanio Bagarinao, Haruo Isoda, Shuji Koyama, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Masahisa Katsuno, Minoru Hoshiyama, Shinji Naganawa, Norio Ozaki, Gen Sobue
  • Journal Title: Magn Reson Med Sci. Volume: - Pages: -
  • DOI: 10.2463/mrms.mp.2020-0081.
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of magnetic resonance angiography as a possible alternative to rotational angiography or computed tomography angiography for assessing cerebrovascular computational fluid dynamics. (2020)
  • Author(s): Yuya Yoneyama, Haruo Isoda, Kenta Ishiguro, Masaki Terada, Masaki Kamiya, Kenichi Otsubo, Roshani Perera, Takashi Mizuno, Atsushi Fukuyama, Kazuya Takiguchi, Tomoya Watanabe, Takafumi Kosugi, Yoshiaki Komori, Shinji Naganawa
  • Journal Title: Phys Eng Sci Med. Volume: 43(4) Pages: 1327-1337
  • DOI: 10.1007/s13246-020-00936-6.
  • Peer Reviewed / Open Access
• [Journal Article] Assessing the Risk of Intracranial Aneurysm Rupture Using Morphological and Hemodynamic Biomarkers Evaluated from Magnetic Resonance Fluid Dynamics and Computational Fluid Dynamics (2020)
  • Author(s): Roshani Perera, Haruo Isoda, Kenta Ishiguro, Takashi Mizuno, Yasuo Takehara, Masaki Terada, Chiharu Tanoi, Takehiro Naito, Harumi Sakahara, Hisaya Hiramatsu, Hiroki Namba, Takashi Izumi, Toshihiko Wakabayashi, Takafumi Kosugi, Yuki Onishi, Marcus Alley, Yoshiaki Komori, Mitsuru Ikeda, Shinji Naganawa
  • Journal Title: Magn Reson Med Sci. Volume: 19(4) Pages: 333-344
  • DOI: 10.2463/mrms.mp.2019-0107.
  • Peer Reviewed / Open Access
• [Journal Article] Three Dimensional Ultra-short Echo Time MRI Can Depict Cholesterol Components of Gallstones Bright. (2020)
  • Author(s): Mamoru Takahashi, Yasuo Takehara, Kenji Fujisaki, Tomoyuki Okuaki, Yukiko Fukuma, Norihiro Tooyama, Katsutoshi Ichijo, Tomoyasu Amano, Satoshi Goshima, Shinji Naganawa
  • Journal Title: Magn Reson Med Sci . Volume: - Pages: -
  • DOI: 10.2463/mrms.mp.2020-0009.
  • Peer Reviewed / Open Access
• [Presentation] Towards the visualization of Neurofluids dynamics by MR using IV-GBCA (2021)
  • Author(s): Shinji Naganawa
  • Organizer: NEUROFLUIDS: Physiology, methods and disease
  • Int'l Joint Research / Invited
• [Presentation] Water Peak MRS：組織中の溶媒の評価の試み (2021)
  • Author(s): 田岡俊昭、伊藤倫太郎、阿部考志、中道玲瑛、中根俊樹、川井 恒、長縄慎二
  • Organizer: 第50回日本神経放射線学会
• [Presentation] ALPS methos (2021)
  • Author(s): 菊田潤子、鎌形康司、高林海斗、染谷由希、田村好史、河盛隆造、錦田裕孝、田岡俊昭、長縄慎二、青木茂樹
  • Organizer: 第50回日本神経放射線学会
• [Presentation] そろそろ知らないと恥ずかしい内リンパ水腫画像 (2021)
  • Author(s): 長縄慎二
  • Organizer: Radiology Today in Setouchi 7th Theme:神経の画像診断
• [Presentation] Glymphatic system仮説とガドリニウム造影剤：変わりつつある常識 (2021)
  • Author(s): 長縄慎二
  • Organizer: エーザイ造影剤インターネットライブセミナー
• [Presentation] Glymphatic system and Gd-based contrast agent (2020)
  • Author(s): Shinji Naganawa
  • Organizer: AIMS Neuro Imaging 2020
  • Int'l Joint Research / Invited
• [Presentation] Multi b-value Diffusion weighted image Diphase Map (MbDDM) to evaluate cerebrospinal fluid dynamics. (2020)
  • Author(s): Toshiaki Taoka, Rintaro Ito, Rei Nakamichi, Toshiki Nakane, Hisashi Kawai, Shinji Naganawa
  • Organizer: ISMRM & SMRT Virtual Conference & Exhibition
  • Int'l Joint Research
• [Presentation] EVAR Does Not Affect Mean Blood Flow Volume and Flow Profile of the Visceral Arteries. (2020)
  • Author(s): Masataka Sugiyama, Yasuo Takehara, Ryota Horiguchi, Takashi Mizuno, Ryota Hyodo, Takasuke Ushio, Tetsuya Wakayama, Atsushi Nozaki, Hiroyuki Kabasawa, Marcus Alley, Satoshi Goshima, Shinji Naganawa
  • Organizer: ISMRM & SMRT Virtual Conference & Exhibition
  • Int'l Joint Research
• [Presentation] Energy loss assessed with 4D-Flow for the normal subjects and patients with an abdominal aortic aneurysm pre and post endovascular aortic repair. (2020)
  • Author(s): Takashi Mizuno, Yasuo Takehara, Masataka Sugiyama, Ryota Horiguchi, Shinji Naganawa, Yasuo Sakurai, Yutaka Kato, Shinji Abe, Haruo Isoda, Tomohiro Sato, Tsuneo Ishiguchi, Masanori Tadokoro, Atsushi Nozaki
  • Organizer: ISMRM & SMRT Virtual Conference & Exhibition
  • Int'l Joint Research
• [Presentation] Quantitative evaluation of distortion in magnetic resonance imaging for radiation treatment planning: Characterization of system-related geometric distortion and effectiveness of distortion correction (2020)
  • Author(s): Yutaka Kato, Kuniyasu Okudaira, Motoki kumagai, Toshiaki Taoka, Takeshi Kamomae, Yoshiyuki Itoh, Shinji Naganawa
  • Organizer: European Congress of Radiology (ECR) 2020
  • Int'l Joint Research
• [Presentation] 【Web特別企画3】 臨床MRI安全運用のための指針に基づく造影剤使用の安全管理と造影剤に関わる最近の話題 (2020)
  • Author(s): 長縄慎二
  • Organizer: 第79回日本医学放射線学会総会
• [Presentation] 【特別企画2】 気持ちが伝わるプレゼンテーション (2020)
  • Author(s): 長縄慎二
  • Organizer: 第79回日本医学放射線学会総会
• [Presentation] 【シンポジウム25】 JJRセミナー『あらためて学ぶ査読のコツ』 (2020)
  • Author(s): 長縄慎二
  • Organizer: 第79回日本医学放射線学会総会
• [Presentation] AiCE併用T2強調像でのNigrosome描出のための至適エコー時間・再構成の検討 (2020)
  • Author(s): 田岡俊昭、川井 恒、中根俊樹、伊藤倫太郎、中道玲瑛、市川和茂、酒井黛呼、長縄慎二
  • Organizer: 第79回日本医学放射線学会総会
• [Presentation] 7T-MRI装置におけるMP2RAGEを用いた視床内部構造の描出 (2020)
  • Author(s): 中根俊樹、福永雅喜、田岡俊昭、川井 恒、加藤 裕、櫻井康雄、長縄慎二
  • Organizer: 第79回日本医学放射線学会総会
• [Presentation] Multi b-value Diffusion weighted image Diphase Map (MbDDM) による脳脊髄液動態の評価 (2020)
  • Author(s): 田岡俊昭、伊藤倫太郎、中道玲瑛、中根俊樹、川井 恒、長縄慎二
  • Organizer: 第49回日本神経放射線学会
• [Presentation] b値拡散強調画像から見た正常圧水頭症の脳脊髄液 (2020)
  • Author(s): 中根俊樹、田岡俊昭、長縄慎二
  • Organizer: 第49回日本神経放射線学会
• [Presentation] 5~10個の脳転移に対するCyberknife治療における単一計画での同時照射法の有用性 (2020)
  • Author(s): 大宝和博、熊谷始紀、髙瀬裕樹、伊藤淳二、棚橋邦明、大岡史治、加茂前健、伊藤善之、長縄慎二
  • Organizer: 日本放射線腫瘍学会第33回学術大会
• [Presentation] 家族性大腸腺腫症に随伴した多発甲状腺癌の一例 (2020)
  • Author(s): 小木曾由梨、佐竹弘子、石垣聡子、長縄慎二
  • Organizer: 第33回頭頸部放射線研究会
• [Presentation] 中枢神経領域での画像診断 おさえておくべきポイント (2020)
  • Author(s): 長縄慎二
  • Organizer: 第24回MR実践講座 共催セミナー
• [Remarks] 名古屋大学医学部放射線医学教室ホームページ
  • URL: https://www.med.nagoya-u.ac.jp/rad/
• [Remarks] 名古屋大学脳とこころの研究センターホームページ
  • URL: https://www.med.nagoya-u.ac.jp/noutokokoro/organization/list.html