Fabrication of donut-shaped drug release sheet that develops in the vitreous body

2019 Fiscal Year Final Research Report

• Project/Area Number: 18K19596
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
• Research Institution: Tohoku University
• Principal Investigator: Abe Toshiaki 東北大学, 医学系研究科, 教授 (90191858)
• Co-Investigator(Kenkyū-buntansha): 梶 弘和 東北大学, 工学研究科, 准教授 (70431525)
• Project Period (FY): 2018-06-29 – 2020-03-31
• Keywords: 硝子体内展開 / 薬剤徐放シート / ドーナツ型

Outline of Final Research Achievements

We aimed to establish a drug delivery device that could be ejected into vitreous safely and attach to the far peripheral region that would not to affect the vision. Using our techniques that were reported previously, we have repeatedly tried to create the proto type device using TEGDM and/or PEGDM and finally developed it as 13mm in diameter, 9mm inner diameter, 50u thickness, 2mm width. Further, we found 3D-printer system made it easier and more accurate than that of hand-made.

Free Research Field

眼科学

Academic Significance and Societal Importance of the Research Achievements

硝子体注射が数々の難治性網膜疾患に有効に利用できることが判明して以来、眼内への薬剤投与は注目を浴びてきている。現在用いられている薬剤の投与方法は直接注射であるがさまざまな合併症の報告があり、また慢性疾患には使用しにくい。我々はさまざまな薬剤徐放システムを開発してきたが、これらの技術を利用すれば確実に眼内に安全に長期間薬剤を徐放でき、慢性の難治性疾患にも利用できると考えられ、その最初のステップになった。