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2020 Fiscal Year Final Research Report

Innovative cell transplantation method using nanoparticles

Research Project

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Project/Area Number 18K19938
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionKeio University

Principal Investigator

Nagase Kenichi  慶應義塾大学, 薬学部(芝共立), 准教授 (10439838)

Co-Investigator(Kenkyū-buntansha) 金澤 秀子  慶應義塾大学, 薬学部(芝共立), 教授 (10240996)
綾野 絵理  慶應義塾大学, 薬学部(芝共立), 研究員 (10424102)
Project Period (FY) 2018-06-29 – 2021-03-31
Keywordsバイオマテリアル / 再生医療 / 組織工学 / DDS
Outline of Final Research Achievements

In the present study, we developed nano-particles composed of polylactic acid-polyglycolic acid (PLGA) were developed. Electrospray method was used for preparation of nano-particles. Diameter, and configuration of nanoparticles were modulated by changing the applied voltage and composition of PLGA solution. The developed nanoparticles have potency for increased cellular function after transplantation with cellular tissue.

Free Research Field

バイオマテリアル

Academic Significance and Societal Importance of the Research Achievements

本研究課題で開発したナノ粒子は、細胞を移植して疾病を治療する再生医療において、疾患部位に移植した細胞の生存率、活性を向上できる可能性がある。これにより、再生医療の治療効果の向上、および、その適用範囲を大幅に拡大できる可能性がある。

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Published: 2022-01-27  

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