International collaborative studies to establish tailormade therapy based on the virulence and antibiotics resistance of H. pylori

2022 Fiscal Year Research-status Report

• Project/Area Number: 18KK0266
• Research Institution: Oita University
• Principal Investigator: 山岡 吉生 大分大学, 医学部, 教授 (00544248)
• Co-Investigator(Kenkyū-buntansha): 松本 昂 大分大学, 医学部, 助教 (50609667) ; 矢原 耕史 国立感染症研究所, 薬剤耐性研究センター, 室長 (70542356)
• Project Period (FY): 2018-10-09 – 2024-03-31
• Keywords: ヘリコバクター・ピロリ / 胃癌 / ベトナム / ブータン / モンゴル / 遺伝子解析 / 国際共同研究

Outline of Annual Research Achievements

発展途上国では、ピロリ菌感染者すべてに除菌療法を行う経済力もなければ十分な内視鏡設備や内視鏡医も存在しない。ピロリ菌培養ができる施設も稀で、効果的な除菌療法も存在しない。そこで本事業では、アジアの発展途上国で胃癌多発国であるモンゴル、ブータン、ベトナムに焦点を当て、現地共同研究者と共同で、除菌を行うべき人および除菌法の選択に有用な未知の病原因子および薬剤耐性関連遺伝子の変異・多型の検索を、次世代シーケンサーを用いた菌側のゲノムワイド関連解析（GWAS）によって行う。最終的には、安価な新規遺伝子解読技術（ナノポア：MinION）による、従来の内視鏡検査および細菌培養を必要としない迅速かつ非侵襲な病原因子および薬剤耐性関連遺伝子検出方法の開発に取り組む。2022年度前半までは、新型コロナウイルス感染禍のため、海外渡航はできなかったが、大分大学に保管しているピロリ菌検体を用いて、従来の次世代シーケンサーおよびナノポアによる解析を進めた。ブータンに関しては、AMED/JICAによる地球規模課題対応国際科学技術協力プログラム（医療分野国際科学技術共同研究開発推進事業）(SATREPS [AMED]) および 地球規模保健課題解決推進のための研究事業 慢性疾患国際アライアンス(GACD国際協調公募)に採択されることができ、2022年8月、2023年3月に渡航することができ、さらなる発展を遂げている。また、ベトナム訪問も2022年11月の28th Conference on Gastroenterology & Hepatology（ベトナム消化器病学会主催）に招待され成果の発表を行うことができた。現在、モンゴルからの国費留学生3名、ブータンからの国費留学生1名が我々の講座で研究を行っており、2023年度には新たにベトナムからの留学生もくる計画である。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

コロナ禍のため、研究期間の延長を行っている点では進捗は遅れていると言えるが、2022年度後半からは海外渡航も再開することができ、また論文発表は継続して行っており、（３）と評価した。

Strategy for Future Research Activity

2023年度は、今までのデータを整理して論文としてまとめていく。薬剤耐性や病原因子にかかわる遺伝子変異を測定できる系を確立し、GWASを用いた解析を進めていく。なお、ブータンでの 事業は、GACD, SATREPS採択という大きな成果を得ることができたため、本事業の終了後も大きな飛躍が期待できる。さらに、モンゴルおよびベトナムにおいても渡航も可能となり、まずは2023年6月にモンゴルでの疫学調査を再開する計画である。

Causes of Carryover

新型コロナ感染の拡大で、海外への渡航が制限されたため、次年度使用額が発生した。次年度は現地での疫学研究を再開していく計画である。

Research Products

• [Int'l Joint Research] ケサル・ギャルポ医科大学/ジグメ・ドルジ・ワンチュク 国立総合病院/保健省 王立疾病 管理センター(ブータン)
  • Country Name: BHUTAN
  • Counterpart Institution: ケサル・ギャルポ医科大学/ジグメ・ドルジ・ワンチュク 国立総合病院/保健省 王立疾病 管理センター
• [Int'l Joint Research] 108病院/チョーライ病院/ハノイ医科大学(ベトナム)
  • Country Name: VIET NAM
  • Counterpart Institution: 108病院/チョーライ病院/ハノイ医科大学
  • # of Other Institutions: 3
• [Int'l Joint Research] モンゴル国立医科学大学/ウランバートル第3病院/モンゴル国立がん研究所(モンゴル)
  • Country Name: MONGOLIA
  • Counterpart Institution: モンゴル国立医科学大学/ウランバートル第3病院/モンゴル国立がん研究所
  • # of Other Institutions: 5
• [Int'l Joint Research] ベイラー医科大学/ヒューストン大学ガルベストン 校(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: ベイラー医科大学/ヒューストン大学ガルベストン 校
• [Journal Article] Cut-off value of clarithromycin resistance in the treatment of Helicobacter pylori infection: how low is low? (2024)
  • Author(s): Hsu Ping-I、Chuah Seng-Kee、Yamaoka Yoshio、Wu Deng-Chyang
  • Journal Title: Gut Volume: 73 Pages: 374～375
  • DOI: 10.1136/gutjnl-2022-329253
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] High levels of fecal calprotectin and C-reactive protein in patients with colitis. (2023)
  • Author(s): Anindita B, Sugihartono T, Miftahussurur M, Maimunah U, Nusi IA, Setiawan PB, Purbayu H, Kholili U, Widodo B, Thamrin H, Vidyani A, Rezkitha YAA, Yamaoka Y.
  • Journal Title: J Med Life. Volume: 16 Pages: 48-51
  • DOI: 10.25122/jml-2021-0311
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mutations Related to Antibiotics Resistance in Helicobacter pylori Clinical Isolates from Bangladesh. (2023)
  • Author(s): Fauzia, Kartika Afrida, Hafeza Aftab, Evariste Tshibangu-Kabamba, Ricky Indra Alfaray, Batsaikhan Saruuljavkhlan, Alain Cimuanga-Mukanya, Takashi Matsumoto, Phawinee Subsomwong, Junko Akada, Muhammad Miftahussurur, and Yoshio Yamaoka.
  • Journal Title: Antibiotics Volume: 12 Pages: -
  • DOI: 10.3390/antibiotics12020279
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pattern and trends of Helicobacter pylori genotypes in gastric cancer: A Kenyan 8-year study. (2023)
  • Author(s): Njenga P, Njau A, Moloo Z, Revathi G, Tshibangu E, Yamaoka Y.
  • Journal Title: Front Med (Lausanne) Volume: 10 Pages: -
  • DOI: 10.3389/fmed.2023.1119513
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel Helicobacter pylori-associated hemolysis Hp0499 and Hp1490 and its association with severity of gastritis. (2023)
  • Author(s): Sang Ketut Widiana, Titong Sugihartono, Dalla Doohan, Langgeng Agung Waskito, Kartika Afrida Fauzia, Yudith Annisa Ayu Rezkitha, Adi Wasis Prakosa, Ricky Indra Alfaray, Camilia Metadea Aji Safitri, Rizki Amalia, Yoshio Yamaoka, Muhammad Miftahussurur.
  • Journal Title: F1000Research Volume: 12 Pages: -
  • DOI: 10.12688/f1000research.122306.1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-Term Resistance-Endurance Combined Training Reduces Pro-Inflammatory Cytokines in Young Adult Females with Obesity. (2023)
  • Author(s): Pranoto A, Cahyono MBA, Yakobus R, Izzatunnisa N, Ramadhan RN, Rejeki PS, Miftahussurur M, Effendi WI, Wungu CDK, Yamaoka Y.
  • Journal Title: Sports (Basel) Volume: 27 Pages: -
  • DOI: 10.3390/sports11030054
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A comprehensive evaluation of an animal model for Helicobacter pylori‐associated stomach cancer: Fact and controversy. (2023)
  • Author(s): Amalia Rizki、Panenggak Nur Syahadati Retno、Doohan Dalla、Rezkitha Yudith Annisa Ayu、Waskito Langgeng Agung、Syam Ari Fahrial、Lubis Masrul、Yamaoka Yoshio、Miftahussurur Muhammad.
  • Journal Title: Helicobacter Volume: 28 Pages: -
  • DOI: 10.1111/hel.12943
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Low-grade intestinal metaplasia in Indonesia: Insights into the expression of proinflammatory cytokines during Helicobacter pylori infection and unique East-Asian CagA characteristics. (2023)
  • Author(s): Miftahussurur Muhammad、Alfaray Ricky Indra、Fauzia Kartika Afrida、Dewayani Astri、Doohan Dalla、Waskito Langgeng Agung、Rezkitha Yudith Annisa Ayu、Utomo Didik Huswo、Somayana Gde、Fahrial Syam Ari、Lubis Masrul、Akada Junko、Matsumoto Takashi、Yamaoka Yoshio.
  • Journal Title: Cytokine Volume: 163 Pages: 156122～156122
  • DOI: 10.1016/j.cyto.2022.156122
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Single 30 min treadmill exercise session suppresses the production of pro-inflammatory cytokines and oxidative stress in obese female adolescents. (2023)
  • Author(s): Pranoto Adi、Rejeki Purwo Sri、Miftahussurur Muhammad、Setiawan Hayuris Kinandita、Yosika Ghana Firsta、Munir Misbakhul、Maesaroh Siti、Purwoto Septyaningrum Putri、Waritsu Cakra、Yamaoka Yoshio.
  • Journal Title: Journal of Basic and Clinical Physiology and Pharmacology Volume: 34 Pages: 235～242
  • DOI: 10.1515/jbcpp-2022-0196
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 日本国内より分離された?Helicobacter pylori の集団構造解析 (2023)
  • Author(s): 友成航平, Saruuljavkhlan Batsaikhan, Ricky Indra Alfaray, Kartika Afrida Fauzia1, 松成修, 赤田純子, 松本昂, 珍田大輔, 下山克, 金城渚, 金城徹, 金城福則, 山岡吉生
  • Journal Title: 大分県医学会雑誌 Volume: 29 Pages: 100-108
  • Peer Reviewed / Open Access
• [Journal Article] Urease Levels and Gastritis Stage in Dyspeptic Patients. (2022)
  • Author(s): Miftahussurur M, Putri CDM, Sugihartono T, Syam AF, Purbayu H, Priyantini D, Kahar H, Rezkitha YAA, Nusi IA, Setiawan PB, Maimunah U, Waskito LA, Kholili U, Widodo B, Vidyani A, Thamrin H, Siregar GA, I'tishom R, Uchida T, Yamaoka Y.
  • Journal Title: Acta Med Indones Volume: 54 Pages: 42-51
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Seroepidemiological survey of the prevalence of Helicobacter pylori infection in Sabah, Malaysia. (2022)
  • Author(s): Mori D, John JL, Sabri SIB, Shaharom SMB, Iha H, Yamaoka Y, Matsumoto T, Ahmed K.
  • Journal Title: IJID Reg Volume: 2 Pages: 126-129
  • DOI: 10.1016/j.ijregi.2021.12.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Helicobacter pylori cagA status and gastric mucosa-associated lymphoid tissue lymphoma: a systematic review and meta-analysis. (2022)
  • Author(s): Keikha Masoud、Sahebkar Amirhossein、Yamaoka Yoshio、Karbalaei Mohsen.
  • Journal Title: Journal of Health, Population and Nutrition Volume: 41 Pages: -
  • DOI: 10.1186/s41043-021-00280-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Next-Generation Sequencing-Based Study of Helicobacter pylori Isolates from Myanmar and Their Susceptibility to Antibiotics. (2022)
  • Author(s): Subsomwong Phawinee、Doohan Dalla、Fauzia Kartika Afrida、Akada Junko、Matsumoto Takashi、Yee Than Than、Htet Kyaw、Waskito Langgeng Agung、Tuan Vo Phuoc、Uchida Tomohisa、Matsuhisa Takeshi、Yamaoka Yoshio.
  • Journal Title: Microorganisms Volume: 10 Pages: 196～196
  • DOI: 10.3390/microorganisms10010196
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Extragastric infection of Helicobacter pylori and alopecia areata: a systematic review and meta-analysis. (2022)
  • Author(s): Ghazvini Kiarash、Yamaoka Yoshio、Karbalaei Mohsen、Keikha Masoud.
  • Journal Title: Reviews in Medical Microbiology Volume: 33 Pages: e114～e118
  • DOI: 10.1097/MRM.0000000000000276
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Editorial: The Role of Mobile Genetic Elements in Bacterial Evolution and Their Adaptability. (2022)
  • Author(s): Vale Filipa F.、Lehours Philippe、Yamaoka Yoshio.
  • Journal Title: Frontiers in Microbiology Volume: 13 Pages: -
  • DOI: 10.3389/fmicb.2022.849667
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genomic differentiation within East Asian Helicobacter pylori. (2022)
  • Author(s): You Yuanhai、Thorell Kaisa、He Lihua、Yahara Koji、Yamaoka Yoshio、Cha Jeong-Heon、Murakami Kazunari、Katsura Yukako、Kobayashi Ichizo、Falush Daniel、Zhang Jianzhong、TEAMHp.
  • Journal Title: Microbial Genomics Volume: 8 Pages: -
  • DOI: 10.1099/mgen.0.000676
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Potassium intake is associated with nutritional quality and actual diet cost: a study at formulating a low sodium high potassium (LSHP) healthy diet. (2022)
  • Author(s): Farapti Farapti、Buanasita Annas、Atmaka Dominikus R.、Setyaningtyas Stefania W.、Adriani Merryana、Rejeki Purwo S.、Yamaoka Yoshio、Miftahussurur Muhammad.
  • Journal Title: Journal of Nutritional Science Volume: 11 Pages: -
  • DOI: 10.1017/jns.2021.104
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Unique TLR9 Activation by Helicobacter pylori Depends on the cag T4SS, But Not on VirD2 Relaxases or VirD4 Coupling Proteins. (2022)
  • Author(s): Tegtmeyer Nicole、Linz Bodo、Yamaoka Yoshio、Backert Steffen.
  • Journal Title: Current Microbiology Volume: 79 Pages: -
  • DOI: 10.1007/s00284-022-02813-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of Nocturnal and Diurnal Moderate-intensity Swimming Exercise on Increasing Irisin Level of Female Mice (Mus musculus). (2022)
  • Author(s): Muhamad FA, Purwo SR, Sulistiawati, Adi P, Kristanti WW, Gadis MS, Ronny L, Yamaoka Y.
  • Journal Title: CMU J Nat Sci Volume: 21 Pages: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Review: Epidemiology of Helicobacter pylori Infection. (2022)
  • Author(s): Alfaray RI , Saruuljavkhlan B. Ansari S, Fauzia KA, Yamaoka Y.
  • Journal Title: Microb Health Dis (European Helicobacter & Microbiota Study Group) Volume: 4 Pages: -
  • DOI: 10.26355/mhd_20229_733
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Helicobacter pylori genomes reveal Paleolithic human migration to the east end of Asia. (2022)
  • Author(s): Suzuki R, Saitou N, Matsuari O, Shiota S, Matsumoto T, Akada J, Kinjo N, Kinjo F, Teruya K, Shimoji M, Shiroma A, Kato M, Satou K, Hirano T, Asaka M, Kryukov K, Moodley Y, Yamaoka Y.
  • Journal Title: iScience Volume: 25 Pages: -
  • DOI: 10.1016/j.isci.2022.104477
  • Peer Reviewed / Open Access
• [Journal Article] The role of non-Helicobacter pylori bacteria in the pathogenesis of gastroduodenal diseases. (2022)
  • Author(s): Waskito LA, Rezkitha YAA, Vilaichone RK, Sugihartono T, Mustika S, Dewa Nyoman Wibawa I, Yamaoka Y, Miftahussurur M.
  • Journal Title: Gut Pathog Volume: 14 Pages: -
  • DOI: 10.1186/s13099-022-00494-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Animal Models and Helicobacter pylori Infection. (2022)
  • Author(s): Ansari S, Yamaoka Y.
  • Journal Title: J Clin Med Volume: 11 Pages: -
  • DOI: 10.3390/jcm11113141
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Macronutrient and micronutrient intake in dietary habits contributed to dyspeptic symptoms in Indonesia. (2022)
  • Author(s): Miftahussurur M., Alfaray R.I., Rezkitha Y.A.A., Fauzia K.A., Maulahela H., Muzellina V.N., Rotty L.S.M., Namara Y.S., Abubakar A., Mustika S., Ratnasari N., Santosa A.Y., Richardo M., Wibawa I.D.N., Adnyana I.K., Rachman P.H., Rachman B.E., Doohan D., Waskito L.A., Yamaoka Y., Khomsan A.
  • Journal Title: Gaceta Medica de Caracas Volume: 130 Pages: 266-275
  • DOI: 10.47307/GMC.2022.130.2.6
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Characterization of Helicobacter pylori tlyA and Its Association with Bacterial Density. (2022)
  • Author(s): Prakosa AW, Miftahussurur M, Juniastuti J, Waskito LA, Doohan D, Fauzia KA, Rezkitha YAA, Sugihartono T, Syam AF, Uchida T, Yamaoka Y.
  • Journal Title: Dig Dis Volume: 40 Pages: 417-426
  • DOI: 10.1159/000518538
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Role of fecal calprotectin as a hypoxic intestinal damage biomarker in COVID-19 patients. (2022)
  • Author(s): Adriana DN, Sugihartono T, Nusi IA, Setiawan PB, Purbayu H, Maimunah U, Kholili U, Widodo B, Thamrin H, Vidyani A, Maulahela H, Yamaoka Y, Miftahussurur M.
  • Journal Title: Gut Pathog Volume: 14 Pages: -
  • DOI: 10.1186/s13099-022-00507-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of gastric microbiota and Helicobacter pylori infection in gastroesophageal reflux disease. (2022)
  • Author(s): Sugihartono T, Fauzia KA, Miftahussurur M, Waskito LA, Rejeki PS, I'tishom R, Alfaray RI, Doohan D, Amalia R, Savitri CMA, Rezkitha YAA, Akada J, Matsumoto T, Yamaoka Y.
  • Journal Title: Gut Pathog Volume: 14 Pages: -
  • DOI: 10.1186/s13099-022-00510-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Helicobacter pylori Infection, Its Laboratory Diagnosis, and Antimicrobial Resistance: a Perspective of Clinical Relevance. (2022)
  • Author(s): Ansari S, Yamaoka Y.
  • Journal Title: Clin Microbiol Rev Volume: 35 Pages: -
  • DOI: 10.1128/cmr.00258-21
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The effect of long-term ketogenic diet on serum adiponectin and insulin-like growth factor-1 levels in mice. (2022)
  • Author(s): Widiatmaja DM, Lutvyani A, Sari DR, Kurniasari H, Meiliana ID, Fasitasari M, Yamaoka Y, Rejeki PS.
  • Journal Title: J Basic Clin Physiol Pharmacol Volume: 33 Pages: 611-618
  • DOI: 10.1515/jbcpp-2021-0287
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Helicobacter pylori infection: is there circulating vacuolating cytotoxin A or cytotoxin-associated gene A protein? (2022)
  • Author(s): Imoto I, Oka S, Katsurahara M, Nakamura M, Yasuma T, Akada J, D'Alessandro-Gabazza CN, Toda M, Horiki N, Gabazza EC, Yamaoka Y.
  • Journal Title: Gut Pathog Volume: 14 Pages: -
  • DOI: 10.1186/s13099-022-00519-8
  • Peer Reviewed / Open Access
• [Journal Article] Helicobacter pylori prevalence in Indonesia: Higher infection risk in Eastern region population. (2022)
  • Author(s): Maulahela H, Doohan D, Annisa Ayu Rezkhita Y, Syam AF, Waskito LA, Metadea Aji Savitri C, Richardo M, Rahman A, Namara YS, Shatri H, Sanityoso A, Alamsyah. Siregar G, Sudarmo E, Uchida T, Vilaichone RK, Yamaoka Y, Muhammad Miftahussurur.
  • Journal Title: F1000Research Volume: 11 Pages: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 第25回 マレーシアでの疫学調査 (2022)
  • Author(s): 山岡吉生
  • Journal Title: Helicobacter Research Volume: 26 Pages: 95-106
• [Journal Article] 35th Workshop of the European Helicobacter and Microbiota Study Group (EHMSG) 2022 (2022年9月8～10日, グラスゴー) (2022)
  • Author(s): 山岡吉生
  • Journal Title: Helicobacter Research Volume: 26 Pages: 226-229
• [Journal Article] 第26回 ドミニカ共和国での疫学調査 その1 (2022)
  • Author(s): 山岡吉生
  • Journal Title: Helicobacter Research Volume: 26 Pages: 233-242
• [Journal Article] Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations. (2022)
  • Author(s): Thorpe HA, Tourrette E, Yahara K, Vale FF, Liu S, Oleastro M, Alarcon T. Perets TT, Latifi-Navid S, Yamaoka Y, Martinez-Gonzalez B, Karayiannis I, Karamitros T, Sgouras DN, Elamin W, Pascoe B, Sheppard SK, Ronkainen J, Aro P, Engstrand L, Agreus L, Suerbaum S, Thorell K, Falush D.
  • Journal Title: Nature Communications Volume: 13 Pages: -
  • DOI: 10.1038/s41467-022-34475-3
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical manifestations of COVID-19 in patients with asthma, hypertension, and diabetes mellitus. (2022)
  • Author(s): Budiarti R, Ediono E, Kalaznykov M, Yamaoka Y, Miftahussurur M.
  • Journal Title: Journal of Medicine and Life Volume: 15 Pages: 1502～1506
  • DOI: 10.25122/jml-2021-0364
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia. (2022)
  • Author(s): Miftahussurur M, Waskito LA, Syam AF, Nusi IA, Wibawa IDN, Rezkitha YAA, Fauzia KA, Siregar GA, Akil F, Waleleng BJ, Saudale AMJ, Abubakar A, Maulahela H, Richardo M, Rahman A, Namara YS, Sudarmo E, Adi P, Maimunah U, Setiawan, Yamaoka Y.
  • Journal Title: Journal of Research in Medical Sciences Volume: 27 Pages: 90～90
  • DOI: 10.4103/jrms.jrms_983_21
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Outer membrane protein HopF is involved in biofilm formation and virulence in Helicobacter pylori. (2023)
  • Author(s): Kartika Afrida Fauzia, Yuri Sugawara, Mayu Obata, Rizki Amalia, Ricky Indra Alfaray, Camilia Metadea, Junko Akada, Takashi Matsumoto, Muhammad Miftahussurur, Yoshio Yamaoka.
  • Organizer: The 19th Korea-Japan H. pylori Joint Symposium
  • Int'l Joint Research
• [Presentation] Microbiome analysis for the diagnosis of H. pylori infection. (2023)
  • Author(s): Yamaoka Y.
  • Organizer: International Symposium on Helicobacter and Upper Gastrointestinal Disease
  • Int'l Joint Research / Invited
• [Presentation] Gastric microbiota and H. pylori in an Asian population. (2023)
  • Author(s): Yamaoka Y.
  • Organizer: International Symposium on Helicobacter and Upper Gastrointestinal Disease
  • Int'l Joint Research / Invited
• [Presentation] Mutations Related to Antibiotics Resistance in Helicobacter pylori Clinical Isolates from Bangladesh. (2023)
  • Author(s): Fauzia, Kartika Afrida, Hafeza Aftab, Evariste Tshibangu-Kabamba, Ricky Indra Alfaray, Batsaikhan Saruuljavkhlan, Alain Cimuanga-Mukanya, Takashi Matsumoto, Phawinee Subsomwong, Junko Akada, Muhammad Miftahussurur, and Yoshio Yamaoka.
  • Organizer: International Symposium on Helicobacter and Upper Gastrointestinal Disease
  • Int'l Joint Research
• [Presentation] Amoxicillin resistance in Helicobacter pylori: Identification of new resistance-conferring mutations in the penicillin-binding protein 1A. (2023)
  • Author(s): Cimuanga-Mukanya A, Tshibangu-Kabamba E, Ngoma-Kisoko PdeJ , Disashi-Tumba G, Matsumoto T,Akada J and Yamaoka Y.
  • Organizer: The 19th Korea-Japan H. pylori Joint Symposium
  • Int'l Joint Research
• [Presentation] Utilization of an Automated Latex Agglutination Turbidity Assay for Assessing Gastric Mucosal Alteration during Helicobacter pylori Infection. (2023)
  • Author(s): Khangai A Akada J, Azzaya D, Batsaikhan S, Gantuya B, Oyuntsetseg K, Davaadaorj D, Matsumoto T, Uchida T, Akada J, and Yamaoka Y.
  • Organizer: The 19th Korea-Japan H. pylori Joint Symposium
  • Int'l Joint Research
• [Presentation] Ancient human footprints left in Helicobacter pylori. (2022)
  • Author(s): Yamaoka Y.
  • Organizer: The 11th Asian Pacific Topic Conference in the 108th General Meeting of the Japanese Society of Gastroenterology
  • Int'l Joint Research / Invited
• [Presentation] Biofilm Formation and antibiotic resistance phenotype of Helicobacter pylori clinical isolates. (2022)
  • Author(s): Fauzia KA, Matsumoto T, Akada J, Yonezawa H, Kamiya S, Yamaoka Y.
  • Organizer: The 18th Japan-Korea H. pylori Joint Symposium,
  • Int'l Joint Research
• [Presentation] The impact of mobile genetic elemants and toxin-antitoxin system on Helicobacter pylori adaptability and antimicrobial resistance: A wisdom from Japan-South Korea whole-genome sequence collection. (2022)
  • Author(s): Alfaray RI, Batsaikhan S, Fauzia KA, Akada J, Matsumoto T, Yamaoka Y.
  • Organizer: The 18th Japan-Korea H. pylori Joint Symposium,
  • Int'l Joint Research
• [Presentation] Identification of the Helicobacter pylori genomic islands in a high gastric cancer region. (2022)
  • Author(s): Batsaikhan S, Alfaray RI, Matsumoto T, Akada J, Yamaoka Y.
  • Organizer: The 18th Japan-Korea H. pylori Joint Symposium,
  • Int'l Joint Research
• [Presentation] Helicobacter pylori and host human genetics in the Caribbean countries. (2022)
  • Author(s): Yamaoka Y.
  • Organizer: IX INTERNATIONAL SYMPOSIUM OF Helicobacter pylori INFECTION AND GASTRIC CANCER
  • Int'l Joint Research / Invited
• [Presentation] Helicobacter pylori isolates from Mongolia describing gastric carcinogenesis and human migration. (2022)
  • Author(s): Gantuya B, Yoshio Y, Oyuntsetseg K.
  • Organizer: 2022 The Japanese Society of Medical Oncology Annual Meeting
  • Int'l Joint Research
• [Presentation] Global genome study of helicobacter pylori phage opens new paradigm on their worldwide distribution, genetic feature, and impacts on antimicrobial resistance, disease advancement, and achievement for phage-based therapy. (2022)
  • Author(s): Alfaray IR, Saruuljavkhlan B, Fauzia KA, Matsumoto T, Yamaoka Y.
  • Organizer: Gut
  • Int'l Joint Research
• [Presentation] A novel pathogen enterococcus hirae induced dysbiosis in the stomach and the genomic instability to promote gastric cancer. (2022)
  • Author(s): Saruuljavkhlan B, Gantuya B, Akada J, Matsumoto T, Alfaray RI, Oyuntsetseg K, Yamaoka Y.
  • Organizer: Gut
  • Int'l Joint Research
• [Presentation] Pro-Inflammatory Cytokine Expression Observed During Helicobacter pylori Infection Revealed the Possibility Reason of Low-Grade Intestinal Metaplasia in Indonesia. (2022)
  • Author(s): Rezkitha, Y.A, Yamaoka Y.
  • Organizer: ASEAN Stomach and Microbiota Study Group
  • Int'l Joint Research
• [Presentation] Worldwide Helicobacter pylori Phage Study: Genome Analysis, Epidemiology, Clinical Data, until New Phage-based Medicine Candidate. (2022)
  • Author(s): Alfaray RI, Yamaoka Y.
  • Organizer: The 21st International Workshop on Campylobacter, Helicobacter and Related Organisms
  • Int'l Joint Research
• [Presentation] Comprehensive Study of Helicobacter pylori Genomic Islands and Their Correlation to Gastric Diseases, Phylogenetic Pattern. (2022)
  • Author(s): Saruuljavkhlan B, Yamaoka Y.
  • Organizer: The 21st International Workshop on Campylobacter, Helicobacter and Related Organisms
  • Int'l Joint Research
• [Presentation] Identification of Flagella and Outer Membrane Protein Genes associated with Biofilm Formation. (2022)
  • Author(s): Kartika Afrida Fauzia, Yamaoka Y.
  • Organizer: The 21st International Workshop on Campylobacter, Helicobacter and Related Organisms
  • Int'l Joint Research
• [Presentation] Effect of gastric microbiota to gastric cancer development. (2022)
  • Author(s): Yamaoka Y.
  • Organizer: 28th Conference on Gastroenterology & Hepatology by VIETNAM ASSOCIATION OF GASTROENTEROLOGY
  • Int'l Joint Research / Invited
• [Presentation] H. pylori and the pathogenesis of gastric cancer. (2022)
  • Author(s): Yamaoka Y.
  • Organizer: ASEAN Gastro2022
  • Int'l Joint Research / Invited
• [Remarks] 大分大学医学部環境・予防医学講座
  • URL: https://oitadepm.com/
• [Remarks] 大分大学 SATREPS
  • URL: https://satreps-oitauniv.com/