Neural circuit formation in the mouse olfactory system

2011 Fiscal Year Final Research Report

• Project/Area Number: 19002012
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: SAKANO Hitoshi 東京大学, 大学院・理学系研究科, 教授 (90262154)
• Project Period (FY): 2007 – 2011
• Keywords: 軸索末端 / シナプス形成 / 神経地図 / 匂い情報処理

Research Abstract

In this project, we have revealed the molecular logics of olfactory map formation. Axons of olfactory sensory neurons (OSNs) are guided to approximate locations in the olfactory bulb by a combination of dorsal-ventral patterning, which is based on anatomical locations of OSNs, and anterior-posterior patterning, which is regulated by cAMP signals whose levels are uniquely determined by odorant receptor species. It was also found that odor information is separately processed by two distinct circuits; one is for hard-wired innate responses, and the other is for memory-based learned behaviors.

Research Products

• [Journal Article] Parallel mitral and tufted cell pathways route distinct odor information to different targets in the olfactory cortex (2012)
  • Author(s): Igarashi, K.M., Ieki, N., An, Myungho, Yamaguchi, Y., Nagayama, S., Kobayakawa, K.,Kobayakawa, R., Tanifuji, M., Sakano, H., Chen, W.R., and Mori, K.
  • Journal Title: J. Neurosci Volume: 32 Pages: 7970-785
• [Journal Article] Axon-axoninteractions in neuronal circuit assembly: lessons from olfactory map formation (2011)
  • Author(s): Imai, T. and Sakano, H.
  • Journal Title: Eur. J. Neurosci. Volume: 34
• [Journal Article] How is the olfactorymap formed and interpreted in the mammalian brain? (2011)
  • Author(s): Mori, K., Sakano, H.
  • Journal Title: Annu. Rev. Neurosci. Volume: 34 Pages: 465-497
• [Journal Article] Elimination of adult-born neurons in the olfactory bulb is promoted during the postprandial period (2011)
  • Author(s): Yokoyama, T.K., Mochimaru, D., Murata, K., Manabe, H., Kobayakawa, K., Kobayakawa, R., Sakano, H., Mori, K., andYamaguchim M.
  • Journal Title: Neuron Volume: 71 Pages: 883-897
• [Journal Article] Two highly homologous mouse odorant receptors encoded by tandemly-linked MOR29A and MOR29B genes respond differently to phenyl ethers (2011)
  • Author(s): Tsuboi, A., Imai., T., Kato, H.K., Matsumoto, H., Igarashi, K.M., Suzuki, M., Mori, K., and Sakano, H.
  • Journal Title: Eur. J. Neurosci. Volume: 33 Pages: 205-213
• [Journal Article] Neural map formation in the mouse olfactory system (2010)
  • Author(s): Sakano H.
  • Journal Title: Neuron Volume: 67 Pages: 530-542
• [Journal Article] Spatial arrangement of glomerularmolecular-feature clusters in theodorant-receptor class domains of the mouse olfactory bulb (2010)
  • Author(s): Matsumoto, H., Kobayakawa, K., Kobayakawa, R., Tashiro, T., Mori, K., Sakano, H., and Mori, K.
  • Journal Title: J. Neurophysiol. Volume: 103 Pages: 3490-3500
• [Journal Article] Themale mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor (2010)
  • Author(s): Haga, S., Hattori, T., Sato, T., Sato, K., Matsuda, S., Kobayakawa, R., Sakano, H., Yoshihara, Y., Kikusui, T., Touhara, K.
  • Journal Title: Nature Volume: 466 Pages: 118-122
• [Journal Article] Sequential arrival and graded secretion of Sema3F by olfactory neuron axons specify map topography at the bulb (2010)
  • Author(s): Takeuchi, H., Inokuchi, K., Aoki, M., Suto, F., Tsuboi, A., Matsuda, I., Suzuki, M., Aiba, A., Serizawa, S., Yoshihara, Y., Fujisawa, H., Sakano, H.
  • Journal Title: Cell Volume: 141 Pages: 1056-1067
• [Journal Article] Topographic Mapping-The Olfactory System (2010)
  • Author(s): Imai, T., Sakano, H., and Vosshall, L.B.
  • Journal Title: Cold Spring Harbor Perspective Biology. Volume: 2 Pages: a001776
• [Journal Article] Pre-target axon sorting establishes the neural map topography (2009)
  • Author(s): Imai, T., Yamazaki, T., Kobayakawa, R., Kobayakawa, K., Abe, T., Suzuki, M., Sakano, H.
  • Journal Title: Science Volume: 325 Pages: 585-590
• [Journal Article] "Odorant Receptor Gene Choice and Axonal Projection in the Mouse Olfactory System" in Chemosensory Systems in Mammals (2009)
  • Author(s): Imai, T. and Sakano, H.
  • Journal Title: Fishes, and Insects(W. Meyerhof and S. Korsching Eds) Pages: 57-75
• [Journal Article] Odorantreceptor-mediated signaling in the mouse (2008)
  • Author(s): Imai, T. and Sakano, H.
  • Journal Title: Curr. Opin. Neurobiol Volume: 18 Pages: 251-260
• [Journal Article] Deletion of the core-H region in mice abolishes the expression of three proximal odorant receptor genes in cis (2007)
  • Author(s): Nishizumi, H., Kumasaka, K., Inoue, N., Nakashima, A., Sakano, H.
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A. Volume: 104 Pages: 20067-20072
• [Journal Article] Innate versus learned odour processing in the mouse olfactorybulb (2007)
  • Author(s): Kobayakawa, K., Kobayakawa, R., Matsumoto, H., Oka, Y., Imai, T., Ikawa, M., Okabe, M., Ikeda, T., Itohara, S., Kikusui, T., Mori, K., Sakano, H.
  • Journal Title: Nature Volume: 450 Pages: 503-508
• [Journal Article] Roles of odorant recweptors in projecting axons in the mouseolfactory system (2007)
  • Author(s): Imai, T. and Sakano, H.
  • Journal Title: Curr. Opin. Neurobiol Volume: 17 Pages: 507-515
• [Journal Article] Functional antigen receptor genes of the agnathanlamprey are constructed by a process involving copy choice (2007)
  • Author(s): Nagawa, F., Kishishita, N., Shimizu, K., Hirose, S., Miyoshi, M., Nezu, J., Nishimura, T., Nishizumi, H., Takahashi, Y., Hashimoto, S., Takeuchi, M., Miyajima, A., Takemori, T., and Sakano, H.
  • Journal Title: Nature Immunol Volume: 8 Pages: 206-213
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2012)
  • Author(s): Sakano, Hitoshi
  • Organizer: AChemS 34^<th> Annual Meeting
  • Place of Presentation: Huntington Beach, CA, USA
  • Year and Date: 20120825-28
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2012)
  • Author(s): Sakano, Hitoshi
  • Organizer: ISOT
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 20120623-27
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2012)
  • Author(s): Sakano, Hitoshi
  • Organizer: Janelia Farm Research Conference: Constructing Neural Circuits
  • Place of Presentation: Janelia Farm Research Campus, Ashburn, VA, USA
  • Year and Date: 20120429-0502
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2012)
  • Author(s): Sakano, Hitoshi
  • Organizer: International Society of DevelopmentalNeuroscience (ISDN)
  • Place of Presentation: Tata Institute, Mumbai, India
  • Year and Date: 20120111-14
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2011)
  • Author(s): Sakano, Hitoshi
  • Organizer: EMBO Olfaction Conference: FromReceptor to Behavior
  • Place of Presentation: The Hebrew University of Jerusalem, Israel
  • Year and Date: 20110206-09
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2010)
  • Author(s): Sakano, Hitoshi
  • Organizer: Gordon Research Conference: NeuralDevelopment
  • Place of Presentation: Salve Regina University, Newport, RI, USA
  • Year and Date: 20100821-25
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2010)
  • Author(s): Sakano, Hitoshi
  • Organizer: Gordon Research Conference: Molecularand Cellular Neurobiology
  • Place of Presentation: Hong Kong University of Science andTechnology, Hong Kong
  • Year and Date: 20100606-11
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2010)
  • Author(s): Sakano, Hitoshi
  • Organizer: Janelia Farm Conference: Form andFunction of the Olfactory System
  • Place of Presentation: Janelia Farm Research Campus, Ashburn, VA, USA
  • Year and Date: 20100523-26
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2010)
  • Author(s): Sakano, Hitoshi
  • Organizer: Francis Crick Symposium on Neuroscience
  • Place of Presentation: CSH Meeting, Asia. Suzhou, China
  • Year and Date: 20100412-17
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2010)
  • Author(s): Sakano, Hitoshi
  • Organizer: Keystone Symposium: Synapses
  • Place of Presentation: Snowbird Resort in Snowbird, UT,USA
  • Year and Date: 20100411-15
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2010)
  • Author(s): Sakano, Hitoshi
  • Organizer: Salk-Nature-IPSEN Symposium on Biological Complexity: Sensory Systems
  • Place of Presentation: Salk Institute, La Jolla, CA, USA
  • Year and Date: 20100113-15
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2009)
  • Author(s): Sakano, Hitoshi
  • Organizer: Scientific Meeting on the Chemical Senses
  • Place of Presentation: Beijing, China
  • Year and Date: 20091115-17
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2009)
  • Author(s): Sakano, Hitoshi
  • Organizer: EMBO Conference Series: Assembly andFunction of Neural Circuits
  • Place of Presentation: Monte Verita, Ascona, Switzerland
  • Year and Date: 20091004-08
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2009)
  • Author(s): Sakano, Hitoshi
  • Organizer: The XIXth ECRO Congress: Taste andSmell
  • Place of Presentation: Sardinia, Italy
  • Year and Date: 20090924-27
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2009)
  • Author(s): Sakano, Hitoshi
  • Organizer: 25^<th> Meeting of the International Society of Chemical Ecology
  • Place of Presentation: Neuchatel, Switzerland
  • Year and Date: 20090823-27
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2009)
  • Author(s): Sakano, Hitoshi
  • Organizer: Janelia Farm Conference: ConstructingNeural Circuits
  • Place of Presentation: Janelia Farm ResearchCampus, Ashburn, VA, USA
  • Year and Date: 20090503-06
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2009)
  • Author(s): Sakano, Hitoshi
  • Organizer: International Symposium on Olfaction andElectric Nose
  • Place of Presentation: Brescia, Italy
  • Year and Date: 20090415-17
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2009)
  • Author(s): Sakano, Hitoshi
  • Organizer: Keystone Symposium: Chemical Senses
  • Place of Presentation: Tahoe City, CA
  • Year and Date: 20090315-19
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system (2009)
  • Author(s): Sakano, Hitoshi
  • Organizer: Keystone Symposium: Axonal Connections
  • Place of Presentation: Keystone, CO,USA
  • Year and Date: 20090217-22
• [Remarks]
  • URL: http://www.biochem.s.u-tokyo.ac.jp/sakano-lab/