血液・循環器・消化器病の診断・治療・予防のための計算ナノバイオメカニクスの創成

2008 Fiscal Year Annual Research Report

• Project/Area Number: 19100008
• Research Institution: Tohoku University
• Principal Investigator: 山口 隆美 Tohoku University, 大学院・医工学研究科, 教授 (30101843)
• Co-Investigator(Kenkyū-buntansha): 石川 拓司 東北大学, 大学院・工学研究科, 准教授 (20313728) ; 松木 範明 東北大学, 大学院・医工学研究科, 特任准教授 (90284520) ; 今井 陽介 東北大学, 大学院・医工学研究科, 助教 (60431524)
• Keywords: 計算生体力学 / 彼環器 / 血液 / 消化器 / 呼吸器 / マラリア / 細胞工学 / 数値流体力学

Research Abstract

2008年度は、脳動脈瘤の発生、成長に係る流体力学的因子の検討を行い、その局在化を説明することができる新しい血行力学因子GONを発見した。このGON因子は血管壁近傍における壁面せん断応力の勾配の時間変動を示すパラメタで、その後、外国の有力グループが追試をして、有効性が確認されている。また、各種分子および血小板の力学的な相互作用から血栓形成に至るプロセスを新たに開発した粒子法を用いて解析し、一次血栓の形成と崩壊に関するシミュレーションの精度を向上させることができた。マラリア感染赤血球のモデルについては、赤血球および内部の病原体(マラリア原虫)の発達段階に応じたレオロジー特性を再現できるモデルを開発し、これを用いて微小循環内の感染赤血球の挙動について検討することができるようになった。とくに、マラリア原虫の発育に応じて、物理的に感染赤血球が硬化する機構と、原虫がもたらす赤血球膜の生物学的な反応の相乗作用をモデル化できるようになったことは、世界的に見て我々のみがなし得る研究である。これらの理論的および数値的な研究を裏付ける骨的で実際の赤血球などを使った確証実験も実施している。このため数値シミュレーションによる流れ中の赤血球挙動の解析結果の妥当性を検証する共焦点micro-PIV計測を行った。この他、微生物や腸内細菌の集団遊泳の大規模数値シミュレーションなど、各課題について広範な研究を実施し、これにより、脳動脈瘤の発生、成長には壁面せん断応力勾配の時間変化が重要な役割を果たしていること等が発見された。これらの研究成果は、英文雑誌論文や国際会議論文、国内学会論文として数多く発表されている。また、国際会議での基調講演、招待講演などを多数行い、研究成果を世界に発信した。

Research Products

• [Journal Article] Can temporal fluctuation in spatial wall shear stress gradie nt initiate a cerebral aneurysm? A proposed novel hemodynamic index, the gradient oscillatory number (GON) (2009)
  • Author(s): Yuji Shimogonya
  • Journal Title: Journal of Biomechanics 42 Pages: 550-554
  • Peer Reviewed
• [Journal Article] In vitro blood flow in a rectangular PDMS microchannel : exper imental observations using a confocal micro-PIV system (2008)
  • Author(s): Rui Lima
  • Journal Title: Biomedical Microdevices 10 Pages: 153-167
  • Peer Reviewed
• [Journal Article] Shear-induced fl uid-tracer diffusion in a semidilute suspension of spheres (2008)
  • Author(s): Biomedical Microdevices
  • Journal Title: PHYSICAL REVIEW E 77 Pages: 041402-1, 041402-9
  • Peer Reviewed
• [Journal Article] Inflow into saccular cerebral aneurysms at arterial bends (2008)
  • Author(s): Yohsuke Imai
  • Journal Title: Annals of Biomedical Engineering 36 Pages: 1489-1495
  • Peer Reviewed
• [Journal Article] Radial dispersion of red blood cells in blood flowing through glass capillaries : The role of hematocrit and geometry (2008)
  • Author(s): Rui Lima
  • Journal Title: Journal of Biomechanics 41 Pages: 2188-2196
  • Peer Reviewed
• [Journal Article] The importance of parent artery geometry in intra-aneurysmal hemodynamics (2008)
  • Author(s): Kodai Sato
  • Journal Title: Medical Engineering & Physics 30 Pages: 774-782
  • Peer Reviewed
• [Journal Article] Computational study on effect of red blood cells on primary thrombus formation (2008)
  • Author(s): Daisuke Mori
  • Journal Title: Thrombosis Research 123 Pages: 114-121
  • Peer Reviewed
• [Journal Article] Development of coherent structures in concentrated susp ensions of swimming model micro-organisms (2008)
  • Author(s): Takuji Ishikawa
  • Journal Title: Journal of Fluid Mechanics 615 Pages: 401-431
  • Peer Reviewed
• [Journal Article] Development of a Wearable System Module for Monitoring Physical and Mental Workload (2008)
  • Author(s): Sinbae Kim
  • Journal Title: Telemedicine and e-Health 14 Pages: 939-945
  • Peer Reviewed
• [Journal Article] Low voltage pulses can induce apoptosis (2008)
  • Author(s): Noriaki Matsuki
  • Journal Title: Cancer Letters 269 Pages: 93-100
  • Peer Reviewed
• [Presentation] Computational biomechanical studies on arterial diseases at the micro and macro levels (2008)
  • Author(s): Takami Yamaguchi
  • Organizer: GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering
  • Place of Presentation: Singapore Singapore
  • Year and Date: 2008-12-09
• [Presentation] Numerical simulation of inspiratory and expiratory pulmonary airflow using a subject-specific model (2008)
  • Author(s): Takahito Miki
  • Organizer: GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering
  • Place of Presentation: Singapore, Singapore
  • Year and Date: 2008-12-09
• [Presentation] A novel hemodynamic index for the initiation of cerebral aneurysms : focusing on temporal variation of spatial wall shear stress gradient (2008)
  • Author(s): Yuji Shimogonya
  • Organizer: GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering
  • Place of Presentation: Singapore, Singapore
  • Year and Date: 2008-12-09
• [Presentation] Behavior of a red blood cell in a simple shear flow simulated by a boundary element method (2008)
  • Author(s): Toshihito Omori
  • Organizer: GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering
  • Place of Presentation: Singapore Singapore
  • Year and Date: 2008-12-09
• [Presentation] Biomechanics of a suspension of micro-organisms (2008)
  • Author(s): Takuji Ishikawa
  • Organizer: The 13th International Conference on Biomedical Engineering
  • Place of Presentation: Singapore,Singapore
  • Year and Date: 2008-12-06
• [Presentation] Three-dimensional simulation of blood flow in malaria infection (2008)
  • Author(s): Yohsuke Imai
  • Organizer: The 13th International Conference on Biomedical Engineering
  • Place of Presentation: Singapore, Singapore
  • Year and Date: 2008-12-05
• [Presentation] Three-dimensional simulation of blood flow in malaria infection (2008)
  • Author(s): Yohsuke Imai
  • Organizer: 7th Intrnational Symposium of 2007 Tohoku University Global COE Program Global Nano-Biomedical Engineering Education and Research Network Centre in the 13th International Conference on Biomedical Engineering, Nano-Biomedical Engineering in the East Asian-Pacific Rim RegionThe 13th International Conference on Biomedical Engineering
  • Place of Presentation: Singapore Singapore
  • Year and Date: 2008-12-05
• [Presentation] Numerical analysis of a stable waltzing pair of Volvox (2008)
  • Author(s): Takuji Ishikawa
  • Organizer: 61st Annual Meeting of the APS Division of Fluid Dynamics
  • Place of Presentation: Texas, USA
  • Year and Date: 2008-11-25
• [Presentation] 7th Intrnational Symposium of 2007 Tohoku University Global COE Program "Global Nano-Biomedical Engineering Ed ucation and Research Network Centre" at National Cheng Kung University of Taiwan (2008)
  • Author(s): Takami Yamaguchi
  • Organizer: Interntional Symposium on Nano-Biomedical Engineering, 7th Intrnational Symposium of 2007 Tohoku University Global COE Program "Global Nano-Biomedical Engineering Education and Research Network Centre", Nano-Biomedical Engineering in the East Asian-Pacific Rim Region
  • Place of Presentation: Tainan, Taiwan
  • Year and Date: 2008-10-16
• [Presentation] Three-dimensional simulation of malaria-infected blood (2008)
  • Author(s): Hitoshi Kondo
  • Organizer: Interntional Symposium on Nano-Biomedical Engineering, 7th Intrnational Symposium of 2007 Tohoku University Global COE Program "Global Nano-Biomedical Engineering Education and Research Network Centre", Nano-Biomedical Engineering in the East Asian-Pacific Rim Region
  • Place of Presentation: Tainan, Taiwan
  • Year and Date: 2008-10-16
• [Presentation] Mixing of red blood cells in a micro-channnel flow under high hematocrit conditions (2008)
  • Author(s): Takuji Ishikawa
  • Organizer: Bioengineering 08
  • Place of Presentation: London, UK
  • Year and Date: 2008-09-19
• [Presentation] A numerical method for simulating micro-scale blood flow in malaria infection (2008)
  • Author(s): Yohsuke Imai
  • Organizer: Bioengineering 08
  • Place of Presentation: London, UK
  • Year and Date: 2008-09-18
• [Presentation] Behavior of a red blood cell in a simple shear flow simulated by a boundary element method (2008)
  • Author(s): Toshihiro Omori
  • Organizer: Bioengineering 08
  • Place of Presentation: London, UK
  • Year and Date: 2008-09-18
• [Presentation] Proposal of a new hemodynamic index for cerebral aneurysm initiation : focusing on temporal fluctuation of spat ial wall shear stress gradient (2008)
  • Author(s): Yuji Shimogonya
  • Organizer: Bioengineering 08
  • Place of Presentation: London, UK
  • Year and Date: 2008-09-18
• [Presentation] Confocal micro-PTV measurements of blood flow in a circular PDMS microchannel (2008)
  • Author(s): Rui Lima
  • Organizer: Bioengineering 08
  • Place of Presentation: London, UK
  • Year and Date: 2008-09-18
• [Presentation] Role of the hematocrit on the radial dispresion of red blood cells in glass capillaries (2008)
  • Author(s): Rui Lima
  • Organizer: 16th Congress of the European Society of Biomechanics
  • Place of Presentation: Lucerne, Switzerland
  • Year and Date: 2008-07-08
• [Presentation] Motion of red blood cells and cell free layer distribut ion in a stenosed microchannel (2008)
  • Author(s): Hiroki Fujiwara
  • Organizer: 16th Congress of the European Society of Biomechanics
  • Place of Presentation: Lucerne, Switzerland
  • Year and Date: 2008-07-07
• [Presentation] Determination of blood cells motions and interactions by a confocal micro-PTV system (2008)
  • Author(s): Rui Lima
  • Organizer: 16th Congress of the European Society of Biomechanics
  • Place of Presentation: Lucerne, Switzerland
  • Year and Date: 2008-07-07
• [Presentation] A numerical model of blood flow with malaria-infected red blood cells (2008)
  • Author(s): Yohsuke Imai
  • Organizer: 16th Congress of the European Society of Biomechanics
  • Place of Presentation: Lucerne, Switzerland
  • Year and Date: 2008-07-07
• [Presentation] Image-based pulmonary airflow simulation using cartesian adaptive mesh refinement method (2008)
  • Author(s): Takahito Miki
  • Organizer: 8th World Congress on Computational Mechanics (WCCM8)/5th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2008)
  • Place of Presentation: Venice, Italy
  • Year and Date: 2008-07-04
• [Presentation] Stokesian-dynamics simulation of a suspension of swimming micro-organisms (2008)
  • Author(s): Takuji Ishikawa
  • Organizer: 8th World Congress on Computational Mechanics (WCCM8)/5th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2008)
  • Place of Presentation: Venice, Italy
  • Year and Date: 2008-07-01
• [Presentation] Three-dimansional simulation of blood flow arising from malaria infection (2008)
  • Author(s): Hitoshi Kondo
  • Organizer: 8th World Congress on Computational Mechanics (WCCM8)/5th European Congress on Computational Methods in Applied Sciences an d Engineering (ECCOMAS 2008)
  • Place of Presentation: Venice, Italy
  • Year and Date: 2008-06-30
• [Presentation] The importance of proliferation of the arterial wall in formation of saccular cerebral aneurysms (2008)
  • Author(s): Yuji Shimogonya
  • Organizer: 2008 Summer Bioengineering Conference
  • Place of Presentation: Florida, USA
  • Year and Date: 2008-06-25
• [Presentation] Multi-scale multi-physics simulations of Biological flows (2008)
  • Author(s): Takami Yamaguchi
  • Organizer: International Symposium on Multi-scale Simulations of Biological and Soft Materials
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2008-06-18
• [Presentation] Pulmonary airflow simulation using subject-specific mod el and cartesian adaptive mesh refinement method (2008)
  • Author(s): Takahito Miki
  • Organizer: 2007 Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network Centre, Tohoku-NUS Student Joint Symposium
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2008-05-12
• [Presentation] Collective motions of locomotive cells in a suspension (2008)
  • Author(s): Takauji Ishikawa
  • Organizer: 2007 Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network Centre, Tohoku-NUS Student Joint Symposium
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2008-05-12
• [Book] Nano-Biomedical Engineering 2009 Proceedings of the Tohoku University Global Centre of Excellence Programme Global Nano-Biomedical Engineering Education and Research Network Centre (2009)
  • Author(s): Takami Yamaguchi
  • Total Pages: 460
  • Publisher: Imperial College Press