Comprehensive study on molecular basis of action of CCN family proteins as novel signal conductors and its translational application

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19109008
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Okayama University
• Principal Investigator: TAKIGAWA Masaharu Okayama University, 大学院・医歯薬学総合研究科, 教授 (20112063)
• Project Period (FY): 2007 – 2011
• Keywords: CCNファミリー / シグナルコンダクター / 結合分子 / 遺伝子発現

Research Abstract

CCNファミリータンパク質が細胞外で交錯する種々のシグナルのオン・オフや強弱を制御することにより、その生物学的作用を発揮するシグナルコンダクターという新概念の分子であることをCCN2を中心にファミリー全体を包括的に捉えて証明する。ついで、その成果を再生医療への応用へと展開し、また、CCNタンパク質発現異常による疾患の治療薬開発のための基礎を築く。

Research Products

• [Journal Article] N-Terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan (2009)
  • Author(s): Aoyama E., Hattori T., Hoshijima M., Araki D., Nishida T., Kubota S., Takigawa M.
  • Journal Title: Biochem.J. 420 Pages: 413-420
  • Peer Reviewed
• [Journal Article] Post-transcriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation (2008)
  • Author(s): Mukudai Y., Kubota S., Kawaki H., Kondo S., Eguchi T., Sumiyoshi K., Ohgawara T., Shimo T., Takigawa M.
  • Journal Title: Mol.Cell.Biol. 28(19) Pages: 6134-6147
  • Peer Reviewed
• [Journal Article] Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel (2008)
  • Author(s): Kikuchi T., Kubota S., Asaumi K., Kawaki H., Nishida T., Kawata K., Mitani S., Tabata Y, Ozaki T., Takigawa M.
  • Journal Title: Tissue Engineering Part A 14(6) Pages: 1089-1098
  • Peer Reviewed
• [Journal Article] Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage (2008)
  • Author(s): Kawaki H., Kubota S., Suzuki A., Lazar N., Yamada, T., Matsumura T., Ohgawara T., Maeda T., Perbal B., Lyons, K. M., Takigawa M.
  • Journal Title: J.Bone Miner.Res. 23(11) Pages: 1751-1764
  • Peer Reviewed
• [Journal Article] Novel transcription factor-like function of human MMP3 regulating CTGF/CCN2 gene (2008)
  • Author(s): Eguchi T., Kubota S., Kawata K., Mukudai Y., Uehara J., Ohgawara T., Ibaragi S., Sasaki A., Kuboki T., Takigawa M.
  • Journal Title: Mol.Cell.Biol. 28 Pages: 2391-2413
  • Peer Reviewed
• [Remarks] ホームページ
  • URL: http://www.dent.okayama-u.ac.jp/seika/index_sc_j.html