2009 Fiscal Year Final Research Report
The role of mechanosensor on cardiovascular disease.
| Project/Area Number |
19200037
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
NARUSE Keiji Okayama University, 大学院・医歯薬学総合研究科, 教授 (40252233)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MORI Satoshi 川崎医科大学, 医学部, 教授 (00294413)
MATSUI Hideki 岡山大学, 大学院・医歯薬学総合研究科, 教授 (30157234)
TOMIZAWA Kazuhito 熊本大学, 大学院・医学薬学研究科, 教授 (40274287)
KATANOSAKA Yuki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60432639)
IRIBE Gentaro 岡山大学, 大学院・医歯薬学総合研究科, 助教 (90284885)
NAKAMURA Kazufumi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10335630)
KUSANO Kengo 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (60314689)
OHE Tohru 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70263556)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Keywords | 心肥大 / 心不全 / メカノセンサー / Ca^<2+>ハンドリング / トランスレーショナルリサーチ |
|---|
| Research Abstract |
In order to elucidate the in vivo mechanotransduction system, it is essential to conduct molecular cell physiological analysis targeting mechanosensitive channel molecules, as well as physiological assessment using knockout mice. In this study, we will examine whether or not hemodynamic loads such as hypertension can cause such dysfunction of the mechanosensitive channel, and explore the roles of the mechanosensor in relation to the formation of hypertrophy and progression of heart failure. The elucidation of the molecular pathway involved in the exacerbation of heart failure will enable us to sift through novel treatment target molecules and treatment research subjects in line with the actual clinical settings.
|
Research Products
(36 results)
-
-
[Journal Article] Improved development of mouse and human embryos using a tilting embryo culture system.2010
Author(s)
Matsuura K, Hayashi N, Kuroda Y, Takiue C, Hirata R, Takenami M, Aoi Y, Yoshioka N, Habara T, Mukaida T, Naruse K
-
Journal Title
Reprod Biomed Online 20
Pages: 358-364
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Impaired NO-mediatevasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats.2007
Author(s)
Kajiya M, Hirota M, Inai Y, Kiyooka T, Morimoto T, Iwasaki T, Endo K, Mohri S, Shimizu J, Yada T, Ogasawara Y, Naruse K, Ohe T, Kajiya F
-
Journal Title
Am J Physiol Heart Circ Physiol 292(6)
Pages: H2737-H2744
Peer Reviewed
-
-
-
[Journal Article] Mechanical stretch enhances IL-8 production in pulmonary microvascular endothelial cells.
Author(s)
Iwaki M, Ito S, Morioka M, Iwata S, Numaguchi Y, Ishii M, Kondo M, Kume H, Naruse K, Sokabe M, Hasegawa Y
-
Journal Title
Biochem Biophys Res Commun
Peer Reviewed
-
-
-
-
-
[Remarks] 2009.12.28日本経済新聞「不妊治療の受精卵培養母胎に似た環境で」
-
[Remarks] 2008.10ジネコ新聞最先端医療の現場を拝見
-
[Remarks] 2008.4.1日刊工業新聞不妊治療で装置出荷卵細胞の培養促進
-
[Remarks] 2008.1.7日本産業新聞「受精胚の培養装置」
-
[Remarks] 2007.12.11日刊工業新聞「不妊治療の装置開発」
-
[Remarks] 2007.12.5日経新聞「泳ぐ力が強い精子選別」
-
[Remarks] 2007.10.10山陽新聞「岡山大の卵細胞培養装置大阪の企業に技術移転tlo」
-
-
-
-
