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2009 Fiscal Year Final Research Report

Clinical application of porous bioactive titanium

Research Project

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Project/Area Number 19200039
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKyoto University

Principal Investigator

NAKAMURA Takashi  Kyoto University, 医学研究科, 教授 (10201675)

Co-Investigator(Kenkyū-buntansha) NEO Masashi  京都大学, 医学研究科, 准教授 (80311736)
NAKAGAWA Yasuaki  独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (90293860)
FUJIBAYASHI Syunsuke  京都大学, 医学研究科, 助教 (30362502)
FUKUSHIMA Masanori  京都大学, 医学研究科, 教授 (80107820)
Project Period (FY) 2007 – 2009
Keywords人工骨 / 多孔体チタン / 生体活性 / レーザープリンティング / 臨床
Research Abstract

We developed bioactive porous titanium as an artificial bone for bone and joint reconstruction. Using this titanium lumbar fusion device was prepared for the treatment of chronic low back disease. Kyoto University institutional review board approved its clinical trial on September 2008. This trial revealed successful bony union was achieved in all five cases by 6 month after surgery without any adverse effects. We established the new system of clinical trial as well as we developed novel treatment.

  • Research Products

    (25 results)

All 2009 2008 2007 2006 2004 2002 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (6 results) Remarks (4 results) Patent(Industrial Property Rights) (6 results)

  • [Journal Article] Reinforcement of tendon attachment to bioactive titanium by BMP-2-induced ectopic bone formation2009

    • Author(s)
      So K, Takemoto M, Fujibayashi S, Neo M, Kokubo T, Nakamura T.
    • Journal Title

      J Biomed Mater Res A

    • Peer Reviewed
  • [Journal Article] 中村孝志生体活性チタンの開発-臨床応用に向けての課題-2009

    • Author(s)
      藤林俊介、竹本充
    • Journal Title

      日本整形外科学会雑誌 Vol.83

      Pages: 469-474

    • Peer Reviewed
  • [Journal Article] 腰椎固定術用チタン多孔体インプラントの開発と臨床試験プロトコル作成の経験から学んだこと2009

    • Author(s)
      竹本充、藤林俊介、根尾昌志、太田雅人、中村孝志
    • Journal Title

      日本脊椎脊髄病学会雑誌 Vol.20

      Pages: 215

    • Peer Reviewed
  • [Journal Article] A new cementless total hip arthroplasty with bioactive titanium porous-coating by alkaline and heat treatment: average 4. 8-year results.2009

    • Author(s)
      Kawanabe K, Ise K, Goto K, Akiyama H, Nakamura T, Kaneuji A, Sugimori T, Matsumoto T.
    • Journal Title

      J Biomed Mater Res B Appl Biomater. 90(1)

      Pages: 476-81

    • Peer Reviewed
  • [Journal Article] Osteoarthritis-Total Hip Replacement Clinical Study Team. Effects of ghrelin treatment on patients undergoing total hip replacement for osteoarthritis: different outcomes from studies in patients with cardiac and pulmonary cachexia.2008

    • Author(s)
      Akamizu T, Iwakura H, Ariyasu H, Murayama T, Sumi E, Teramukai S, Goto K, Ohnishi E, Akiyama H, Kawanabe K, Nankaku M, Ichihashi N, Tsuboyama T, Tamai K, Kataoka M, Nakamura T, Kangawa K
    • Journal Title

      J Am Geriatr Soc. 56(12)

      Pages: 2363-5

    • Peer Reviewed
  • [Journal Article] Onishi E, Enhancement of bone-bonding ability of bioactive titanium by prostaglandin E2 receptor selective agonist.2008

    • Author(s)
      Fujibayashi S, Takemoto M, Neo M, Maruyama T, Kokubo T, Nakamura T.
    • Journal Title

      Biomaterials. 29(7)

      Pages: 877-83

    • Peer Reviewed
  • [Journal Article] A porous bioactive titanium implant for spinal interbody fusion: an experimental study using a canine model.2007

    • Author(s)
      Takemoto M, Fujibayashi S, Neo M, So K, Akiyama N, Matsushita T, Kokubo T, Nakamura T.
    • Journal Title

      J Neurosurg Spine. 7(4)

      Pages: 435-43

    • Peer Reviewed
  • [Journal Article] 生体活性チタン2007

    • Author(s)
      藤林俊介、竹本充、大槻文悟、秋山典宏、根尾昌志、川那辺圭一、中村孝志
    • Journal Title

      日本整形外科学会雑誌 Vol.81,S21

    • Peer Reviewed
  • [Journal Article] 生体活性処理焼結ポーラスチタンにおける骨伝導能と骨誘導能2007

    • Author(s)
      竹本充、藤林俊介、根尾昌志、秋山典宏、小久保正、中村孝志
    • Journal Title

      日本整形外科学会雑誌 Vol.81,S859

    • Peer Reviewed
  • [Presentation] 腰椎固定術用チタン多孔体インプラントの開発と臨床試験プロトコル作成の経験から学んだこと2009

    • Author(s)
      竹本充、藤林俊介、根尾昌志、太田雅人、中村孝志
    • Organizer
      第38回日本脊椎脊髄病学会
    • Place of Presentation
      神戸
    • Year and Date
      20090423-20090425
  • [Presentation] Osteoinductive Ti metal: Development and clinical applications.2009

    • Author(s)
      Takemoto M, Fujibayashi S, Matsushita T, Kokubo T, Nakamura T
    • Organizer
      Biomaterials Asia 2009
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      20090405-20090408
  • [Presentation] バイオマテリアルによる骨再生「チタン金属による骨再生」2008

    • Author(s)
      藤林俊介
    • Organizer
      第26回日本骨代謝学会学術集会ミニシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      20081029-20081030
  • [Presentation] A novel biomaterial for spinal fusion: An experimental study in a canine lumbar interbody fusion model2008

    • Author(s)
      M. Takemoto, S. Fujibayashi, M. Neo, T. Nakamura
    • Organizer
      Spineweek 2008
    • Place of Presentation
      Eurospine, Geneva, Switzerland
    • Year and Date
      20080526-20080531
  • [Presentation] 生体活性処理焼結ポーラスチタンにおける骨伝導能と骨誘導能2007

    • Author(s)
      竹本充、藤林俊介、根尾昌志、秋山典宏、小久保正、中村孝志
    • Organizer
      第22回日本整形外科学会基礎学術集会
    • Place of Presentation
      浜松
    • Year and Date
      20071025-20071026
  • [Presentation] 生体活性チタン2007

    • Author(s)
      藤林俊介、竹本充、大槻文悟、秋山典宏、根尾昌志、川那辺圭一、中村孝志
    • Organizer
      第80回日本整形外科学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      20070524-20070527
  • [Remarks] 2009.1.6新聞各紙での臨床試験に関する報道(共同通信、産経新聞、毎日新聞、京都新聞)

  • [Remarks] 2009.1.6読売テレビ・イブニングニュースでの臨床試験に関する報道

  • [Remarks] 2009.2.11テレビ大阪News Biz「特集腰痛治療最前線」

  • [Remarks] 2009.2.20週刊ポスト「第149回医心伝身」腰椎変性疾患による腰痛に多孔体チタン製人工骨手術

  • [Patent(Industrial Property Rights)] 人工骨の製造方法2007

    • Inventor(s)
      中村孝志藤林俊介, 他3名
    • Industrial Property Rights Holder
      京都大学中部大学佐川印刷株式会社
    • Industrial Property Number
      特許PCT/JP2007/000233
    • Filing Date
      2007-03-16
  • [Patent(Industrial Property Rights)] 人工骨の製造方法2007

    • Inventor(s)
      中村孝志藤林俊介, 他3名
    • Industrial Property Rights Holder
      京都大学中部大学佐川印刷株式会社
    • Industrial Property Number
      特許特願2008-511947
    • Filing Date
      2007-03-16
  • [Patent(Industrial Property Rights)] 生体インプラント材料の製造方法2006

    • Inventor(s)
      小久保正中村孝志金鉉敏
    • Industrial Property Rights Holder
      財団法人イオン工学振興財団
    • Industrial Property Number
      特許特許第3877505号
    • Filing Date
      2006-11-10
  • [Patent(Industrial Property Rights)] 生体骨誘導性の人工骨とその製造方法2004

    • Inventor(s)
      中村孝志小久保正, 他3名
    • Industrial Property Rights Holder
      関西TLO株式会社
    • Industrial Property Number
      特許特願2005-507965
    • Filing Date
      2004-01-07
  • [Patent(Industrial Property Rights)] 生体骨誘導性の人工骨とその製造方法2004

    • Inventor(s)
      中村孝志小久保正, 他3名
    • Industrial Property Rights Holder
      関西TLO株式会社
    • Industrial Property Number
      特許PCT/JP2004/000042
    • Filing Date
      2004-01-07
  • [Patent(Industrial Property Rights)] 生体親和性に優れた骨代替材料およびその製造方法2002

    • Inventor(s)
      小久保正中村孝志, 他4名
    • Industrial Property Rights Holder
      小久保正中村孝志, 他2名
    • Industrial Property Number
      特許特願2002-302167
    • Filing Date
      2002-10-16

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Published: 2011-06-18   Modified: 2016-04-21  

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