2010 Fiscal Year Final Research Report
Development of multifunctional nano-vesicles having target accumulation, temperature-response, and imaging abilities
| Project/Area Number |
19200040
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
KONO Kenji Osaka Prefecture University, 大学院・工学研究科, 教授 (90215187)
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| Co-Investigator(Kenkyū-buntansha) |
AOSHIMA Sadahito 大阪大学, 大学院・理学研究科, 教授 (50183728)
ISHIZAKA Yukihito 国立国際医療センター研究所, 部長 (30281687)
KOJIMA Chie 大阪府立大学, 大学院・21世紀科学研究機構, 講師 (50405346)
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| Project Period (FY) |
2007 – 2010
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| Keywords | ナノ医療 / ナノカプセル / ドラッグデリバリー / 可視化 / MRI / がん治療 / 診断 |
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| Research Abstract |
In this study, we successfully developed a new type of multifunctional nanovesicles that have tumor-accumulating, temperature-responsive drug releasing, and MRI-detectable functions. Highly efficient tumor chemotherapy was achieved using the multifunctional nanovesicles. Results might lead to the development of personalized chemotherapy that provides best chemotherapy optimized to individual patient.
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[Journal Article] Multifunctional liposomes having temperature-triggered release and magnetic resonance imaging for tumor-specific chemotherapy2011
Author(s)
K. Kono, S. Nakashima, D. Kokuryo, I. Aoki, H. Shimomoto, S. Aoshima, K. Maruyama, E. Yuba, C. Kojima, A. Harada, Y. Ishizaka
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Journal Title
Biomaterials 32
Pages: 1387-1395
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