2009 Fiscal Year Final Research Report
Activation of Carbon-Carbon Bonds by Transition Metals
| Project/Area Number |
19205013
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
MURAKAMI Masahiro Kyoto University, 大学院・工学研究科, 教授 (20174279)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Takanori 東京理科大学, 理学部, 講師 (80359778)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 炭素-炭素結合切断 / 炭素-炭素結合形成 / 遷移金属触媒 / 白金 / 多環芳香族炭化水素 / アズレン / 不活性結合活性化 / 環化異性化反応 |
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| Research Abstract |
New carbon-carbon bond cleaving reactions catalyzed by transition metals were developed. Various carbon skeletons were constructed by utilization of these reactions. In particular, enantioselective cleavage of a carbon-carbon bond led to the formation of quaternary chiral carbon centers. For example, six-membered benzolactones having a chiral quaternary center at the benzylic position were synthesized with high enantioselectivity. Indane skeletones having chiral quaternary centers at both benzylic positions were constructed in a stereoselective manner from cyclobutanols with an aryl substituent at the 3-position. A new method to synthesize azulene derivatives, which were attractive as organic materials, was also developed.
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