2010 Fiscal Year Final Research Report
Chemical Biology of DNA Structure and Functions
| Project/Area Number |
19205023
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyoto University |
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Principal Investigator |
SUGIYAMA Hiroshi Kyoto University, 大学院・理学研究科, 教授 (50183843)
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| Co-Investigator(Kenkyū-buntansha) |
BANDO Toshikazu 京都大学, 大学院・理学研究科, 准教授 (20345284)
SHINOHARA Kenichi 京都大学, 大学院・理学研究科, 助教 (70378561)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 核酸 / 蛋白質 / 構造機能解析 / 光反応性 / 修飾塩基 / 5-ハロウラシル |
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| Research Abstract |
Our research group are utilizing photo-irradiation of BrU substituted DNA to investigate the DNA structure and reactivity relationship at a molecular level. These studies demonstrated the detailed relationships between the local DNA structures and the photochemical products of photoinduced hydrogen abstraction by the resulting uracil-5-yl radicals, and proposed that this photochemical method can be used to detect DNA structures. Dynamic DNA conformational change which directly relates to specific gene expression can chemically be understood.
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[Journal Article] Chiral Wedge Moleculeinhibits Telomerase Activity.2010
Author(s)
Shinohara, K., Sannohe,Y., Kaieda, S., Tanaka, K., Osuga, H., Xu, Y., Bando, T., Sugiyama, H.
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Journal Title
J.Am.Chem.Soc. 132
Pages: 3778-3782
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[Journal Article] Comparative Analysis of DNA Alkylation by Conjugates between Pyrrole-Imidazole Hairpin Polyamides and Chlorambucil or seco-CBI.2010
Author(s)
Minoshima, M., Bando, T., Shinohara, K., Kashiwazaki, K., Nishijima, S., Sugiyama, H.
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Journal Title
Bioorg.Med.Chem. 18
Pages: 1236-1243
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[Journal Article] Alkylation of a Human Telomere Sequence by Heterotrimeric Chlorambucil PI Polyamide Conjugates.2010
Author(s)
Kashiwazaki, G., Bando, T., Shinohara, K., Mioshima, M., Kumamoto, H., Nishijima, S., Sugiyama, H.
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Journal Title
Bioorg.Med.Chem. 18
Pages: 2887-2893
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[Journal Article] The Orientation of the Ends of G-Quadruplex Structures Investigated using End-Extended Oligonucleotides.2009
Author(s)
Sannohe, Y., Sato, K., Matsugami, A., Shinohara, K., Mashimo, T., Katahira, M., Sugiyama, H.
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Journal Title
Bioorg.Med.Chem. 19
Pages: 1870-1875
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[Journal Article] Cooperative Alkylation of Double strand Human Telomere Repeat Sequences by PI Polyamides with 11-Base-pair Recognition Based on a Heterotrimeric Design.2009
Author(s)
Kashiwazaki, G., Bando, T., Shinohara, K., Minoshima, M., Nishijima, S., Sugiyama, H.
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Journal Title
Bioorg.Med.Chem. 17
Pages: 1393-1397
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[Journal Article] Requirement of β-Alanine Components in Sequence-Specific DNA Alkylation by Pyrrole-Imidazole Conjugates with Seven-Base Pair Recognition.2008
Author(s)
Bando, T., Minoshima, M., Kashiwazaki, G., Shinohara, K., Sasaki, S., Fujimoto, J., Ohtsuki, A., Murakami, M., Nakazono, S., Sugiyama, H.
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Journal Title
Bioorg.Med.Chem. 16
Pages: 2286-2291
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[Journal Article] DNA Alkylation by Pyrrole-Imidazole seco-CBI Conjugates with an Indole Linker : Sequence-Specific DNA Alkylation with Ten-Base-Pair Recognition throug Hetelodimer Formation.2007
Author(s)
Minoshima, M., Bando, T., Sasaki, S., Shinohara, K., Shimizu, T., Fujimoto, J., Sugiyama, H.
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Journal Title
J.Am.Chem.Soc. 129
Pages: 5384-5390
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